Epithelial cell migration in the intestine
Epithelial cell migration in the intestine
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DOI：
10.1006/cbir.1996.0018
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发表时间：
1996-02-01
影响因子：
3.9
通讯作者：
Heath, JP
中科院分区：
文献类型：
--
作者：
Heath, JP
尽管我们对细胞骨架和基质受体在细胞运动中的作用的理解取得了重大进展，主要来自上皮细胞片和分离细胞的体外运动研究，但上皮细胞在成人肠中的迁移机制仍然是一个谜。上皮细胞骨架的主要功能似乎是维持面向肠腔的上皮的顶端区域。在那里，我们发现了刷状边界及其相关酶，以及赋予上皮内聚性和屏障功能的细胞间粘附复合物。奇怪的是，在基底膜附近的上皮基底区几乎没有有组织的细胞骨架，而基底膜被认为是上皮迁移的地方。在这篇简短的综述中，我将重点从我们对上皮结构的理解和伤口愈合的研究中了解上皮迁移，并指出未来研究的一些途径。(C) 1996学术出版社有限公司
Despite significant advances in our understanding of the roles of the cytoskeleton and matrix receptors in cell locomotion, derived largely from in vitro studies on the movement of epithelial cell sheets and isolated cells, the mechanism of epithelial cell migration in the adult intestine remains an enigma. The primary function of the epithelial cell cytoskeleton seems to be in the maintenance of the apical region of the epithelium facing the gut lumen. There we find the brush border, with its associated enzymes, and the intercellular adhesion complexes that give the epithelium its cohesiveness and its barrier function. Curiously, there is little in the way of an organized cytoskeleton in the basal region of the epithelium adjacent to the basement membrane on which the epithelium is presumed to migrate. In this short review, I focus on what is known about epithelial migration from our understanding of the structure of the epithelium and from studies on wound healing, and indicate some avenues for future study. (C) 1996 Academic Press Limited