Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus.
Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus.
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DOI：
10.1371/journal.pone.0162608
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Schmieder RE
中科院分区：
文献类型：
--
作者：
Jumar A;Harazny JM;Ott C;Friedrich S;Kistner I;Striepe K;Schmieder RE
在2型糖尿病中，毛细血管稀疏在终末器官损害的发病机制中起关键作用。我们研究了早期疾病患者的视网膜毛细血管密度。这项横断面研究比较了73例2型糖尿病患者、55例健康对照组和134例1期或2期高血压患者的视网膜毛细血管稀疏情况，这些视网膜毛细血管稀疏情况是通过毛细血管间距（ICD）和毛细血管面积（CapA）非侵入性和体内扫描激光多普勒血流仪测量的。在调整两组之间的心血管危险因素差异后，糖尿病患者的ICD大于健康对照组（23.2±5.5 vs 20.2±4.2，p = 0.013），CapA小于健康对照组（1592±595 vs 1821±652，p = 0.019）。与高血压患者相比，糖尿病患者的ICD（23.1±5.8，p = 0.781）和CapA（1556±649，p = 0.768）无差异。在2型糖尿病的早期阶段，与健康个体相比，患者表现出毛细血管稀疏。
In diabetes mellitus type 2, capillary rarefaction plays a pivotal role in the pathogenesis of end-organ damage. We investigated retinal capillary density in patients with early disease. This cross-sectional study compares retinal capillary rarefaction determined by intercapillary distance (ICD) and capillary area (CapA), measured non-invasively and in vivo by scanning laser Doppler flowmetry, in 73 patients with type 2 diabetes, 55 healthy controls and 134 individuals with hypertension stage 1 or 2. In diabetic patients, ICD was greater (23.2±5.5 vs 20.2±4.2, p = 0.013) and CapA smaller (1592±595 vs 1821±652, p = 0.019) than in healthy controls after adjustment for differences in cardiovascular risk factors between the groups. Compared to hypertensive patients, diabetic individuals showed no difference in ICD (23.1±5.8, p = 0.781) and CapA (1556±649, p = 0.768). In the early stage of diabetes type 2, patients showed capillary rarefaction compared to healthy individuals.