OCULAR SEQUELAE OF PRETERM BIRTH AND THEIR RELATION TO ULTRASOUND EVIDENCE OF CEREBRAL-DAMAGE
OCULAR SEQUELAE OF PRETERM BIRTH AND THEIR RELATION TO ULTRASOUND EVIDENCE OF CEREBRAL-DAMAGE
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DOI：
10.1136/bjo.70.6.463
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发表时间：
1986-06-01
影响因子：
4.1
通讯作者：
HOPE, P
中科院分区：
文献类型：
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作者：
HUNGERFORD, J;STEWART, A;HOPE, P
对1979年至1982年出生于新生儿重症监护病房的177例极早产儿（< 33周妊娠）的眼睛进行了检查，作为神经发育结果的持续随访研究的一部分。177名婴儿中有37名（21%）被诊断为眼部病理学：14名（8%）早产儿视网膜病变（ROP），其中3名（5%）婴儿进行性视网膜病变，9名（5%）婴儿视力成熟延迟（DVM）。177名婴儿中有26名（15%）的眼部病理是永久性的。屈光不正是最常见的问题，在14名患有ROP的婴儿中有8名，在9名患有DVM的婴儿中有2名，屈光不正会造成永久性后遗症。ROP的存在或不存在与广泛的前瞻性编码的围产期变量和常规新生儿超声脑扫描的结果和在生命的前18个月内进行的神经发育随访评估有关。与以前的研究一样，ROP婴儿的妊娠期较短，出生体重较低，需要氧疗的时间比未受影响的婴儿长，但这种情况与其他呼吸系统疾病指数的相关性很弱。相反，ROP与脑损伤的证据密切相关，通常与缺氧缺血性损伤一致。我们的结论是，一个潜在的病变在ROP可能是缺氧缺血性损害视网膜循环。
The eyes of 177 very preterm (< 33 weeks'' gestation) infants, born betwen 1979 amd 1982 and admitted to a neonatal intensive care unit, were examined as part of an ongoing follow-up study of neurodevelopmental outcome. Ocular pathology was diagnosed in 37 (21%) of the 177 infants: 14 (8%) had retinopathy of prematurity (ROP).sbd.progressive in three.sbd.and nine (5%) infants had delayed visual maturation (DVM). The ocular pathology was permanent in 26 (15%) of the 177 infants. Refractive errors were the commonest problem and accounted for permanent sequelae in eight of the 14 infants with ROP and two of the nine with DVM. The presence or absence of ROP was related to a wide range of prospectively coded perinatal variables and to the results of routine neonatal ultrasound brain scans and neurodevelopmental follow-up assessments made in the first 18 months of life. As in previous studies, infants with ROP were of shorter gestation, lower birth weight, and required oxygen therapy for longer than unaffected infants, but the condition was only weakly associated with other indices of respiratory illness. In contrast, ROP was strongly associated with evidence of brain damage, often consistent with hypoxic ischaemic injury. We conclude that an underlying lesion in ROP may be hypoxic ischaemic damage to the retinal circulation.