Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein.
Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein.
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上皮糖蛋白是上皮细胞表面抗原家族的成员，与巢蛋白（一种基质粘附蛋白）同源。
DOI：
10.1073/pnas.87.7.2755
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发表时间：
1990
影响因子：
11.1
通讯作者：
Brand,SJ
中科院分区：
文献类型：
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作者：
Simon,B;Podolsky,DK;Moldenhauer,G;Isselbacher,KJ;Gattoni-Celli,S;Brand,SJ
细胞表面抗原，上皮糖蛋白，由单抗HEA 125定义，在几乎所有的上皮细胞膜上表达，但不在中胚层或神经细胞膜上表达。用HEA 125抗体富集法从COS细胞中瞬时表达的结肠癌细胞中分离出编码上皮糖蛋白的基因。上皮糖蛋白抗原的序列与单抗KS 1/4识别的细胞膜蛋白相同，与肿瘤相关抗原GA733同源。这些蛋白质与Nidogen有序列同源性，Nidogen是一种细胞外基质成分，似乎参与细胞-基质黏附。这些蛋白质还共享在层粘连蛋白(一种基质黏附蛋白)和胎盘蛋白12(一种在怀孕期间分泌的胰岛素样生长因子I结合蛋白，参与调节胎儿生长)的B1链中的同源结构域。这个共同的结构域在甲状腺球蛋白前体中也重复多次。这些发现表明，上皮糖蛋白是一种参与细胞-细胞或细胞-基质相互作用的细胞表面分子。
The cell surface antigen, epithelial glycoprotein, defined by the monoclonal antibody HEA 125, is expressed on virtually all epithelial cell membranes but not on mesodermal or neural cell membranes. The cDNA encoding epithelial glycoprotein was isolated by HEA 125 antibody enrichment of colon tumor cDNA expressed transiently in COS cells. The sequence of the epithelial glycoprotein antigen is identical to the cell membrane protein recognized by the monoclonal antibody KS 1/4 and is homologous to the tumor-associated antigen GA733. These proteins share sequence homology to nidogen, an extracellular matrix component that appears to participate in cell-matrix adhesion. These proteins also share a homologous domain found in the B1 chain of laminin, a matrix adhesion protein, and placental protein 12, an insulin-like growth factor I binding protein secreted during pregnancy that has been implicated in regulation of fetal growth. This common domain is also repeated multiple times within the thyroglobulin precursor. These findings suggest epithelial glycoprotein is a cell surface molecule involved in cell-cell or cell-matrix interaction.
从羊水中分离出两种胎儿抗原（FA-1 和 FA-2）和子宫内膜蛋白（PP12 和 PP14）：定位于胎儿和成年女性生殖道。
DOI：
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发表时间：
1989
期刊：
European Journal of Obstetrics, Gynecology, and Reproductive Biology
影响因子：
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作者：
D. Tornehave;T. Fay;B. Teisner;J. Chemnitz;J. Westergaard;J. Grudzinskas
通讯作者：
J. Grudzinskas
计算机物理通信。
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