MolabIS - An integrated information system for storing and managing molecular genetics data
MolabIS - An integrated information system for storing and managing molecular genetics data
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DOI：
10.1186/1471-2105-12-425
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发表时间：
2011-10-31
影响因子：
3
通讯作者：
Groeneveld, Eildert
中科院分区：
文献类型：
--
作者：
Truong, Cong V. C.;Groeneveld, Linn F.;Groeneveld, Eildert
背景：在遗传学研究中，样本的长期保存、数据流的跟踪和数据导出对于后续分析非常重要。因此，分子实验室确实需要一个适当的信息系统来处理越来越多的数据从不同的project.Results：我们已经开发了一个分子实验室信息管理系统（MolabIS）。它是作为一个基于网络的系统实施的，允许用户在其工作流程的每一步捕获原始数据。MolabIS提供了管理个人信息、跟踪样本和存储位置、捕获原始文件、从外部文件导入最终数据、搜索结果、访问和修改数据的基本功能。其他重要功能包括生成可打印报告的选项，以及将序列和微卫星数据转换为各种数据格式的选项，这些数据格式可用作后续分析的输入文件。此外，MolabIS还提供了一个工具，数据migration.Conclusions：MolabIS是专为中小型实验室进行桑格测序和微卫星基因分型存储和有效地处理相对大量的数据。MolabIS不仅有助于避免耗时的任务，而且还确保了数据的可用性，以供进一步分析。该软件被打包为一个虚拟设备，可以在不同的平台上运行（例如，G. Linux、Windows）。MolabIS可以分发到广泛的分子遗传学实验室，因为它是根据通用数据模型开发的。MolabIS在GPL下发布，可在http://www.molabis.org上免费获得。
Background: Long-term sample storage, tracing of data flow and data export for subsequent analyses are of great importance in genetics studies. Therefore, molecular labs do need a proper information system to handle an increasing amount of data from different projects.Results: We have developed a molecular labs information management system (MolabIS). It was implemented as a web-based system allowing the users to capture original data at each step of their workflow. MolabIS provides essential functionality for managing information on individuals, tracking samples and storage locations, capturing raw files, importing final data from external files, searching results, accessing and modifying data. Further important features are options to generate ready-to-print reports and convert sequence and microsatellite data into various data formats, which can be used as input files in subsequent analyses. Moreover, MolabIS also provides a tool for data migration.Conclusions: MolabIS is designed for small-to-medium sized labs conducting Sanger sequencing and microsatellite genotyping to store and efficiently handle a relative large amount of data. MolabIS not only helps to avoid time consuming tasks but also ensures the availability of data for further analyses. The software is packaged as a virtual appliance which can run on different platforms (e. g. Linux, Windows). MolabIS can be distributed to a wide range of molecular genetics labs since it was developed according to a general data model. Released under GPL, MolabIS is freely available at http://www.molabis.org.