Lung function and incident coronary heart disease - The atherosclerosis risk in communities study
Lung function and incident coronary heart disease - The atherosclerosis risk in communities study
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DOI：
10.1093/aje/kwg276
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发表时间：
2003-12-15
影响因子：
5
通讯作者：
Heiss, G
中科院分区：
文献类型：
--
作者：
Schroeder, EB;Welch, VL;Heiss, G
作者在社区动脉粥样硬化风险研究（1987-1998）的14，480名参与者中检查了肺功能（通过1秒用力呼气量（FEV 1）和用力肺活量测量）与10年冠心病发病率之间的关系。FEV 1和用力肺活量使用单独的比例风险模型，包括性别-特异性肺功能四分位数和肺功能x性别相互作用项。肺功能和冠心病之间的关联在两种性别中都有观察到，在女性中更强。校正年龄、种族、研究中心、身高、身高平方、吸烟和心血管疾病风险因素后，FEV 1第一（最低）、第二和第三四分位数的风险比为3.70（95%置信区间（CI）：2.19，6.24），2.54（95% CI：1.49，4.32）和2.25（95% CI：1.31，3.87），男性为1.51（95% CI：1.07，2.13）、1.59（95% CI：1.15，2.20）和1.52（95% CI：1.10，2.09）。按吸烟状况分层后，在每个吸烟组中观察到女性的相关性，而男性的相关性较弱且不一致。用力肺活量也获得了类似的结果。这项分析表明，女性的肺功能与冠心病发病率之间的相关性可能比男性更强。
The authors examined the association between lung function, as measured by forced expiratory volume in 1 second (FEV1) and forced vital capacity, and the 10-year incidence of coronary heart disease among 14,480 participants in the Atherosclerosis Risk in Communities Study (1987-1998). Separate proportional hazards models were used for FEV1 and forced vital capacity, with gender-specific lung function quartiles and lung function x gender interaction terms. An association between lung function and coronary heart disease was observed in both genders and was stronger among women. After adjustment for age, race, study center, height, height squared, smoking, and cardiovascular disease risk factors, the hazard ratios for the first (lowest), second, and third quartiles of FEV1 were 3.70 (95% confidence interval (CI): 2.19, 6.24), 2.54 (95% CI: 1.49, 4.32), and 2.25 (95% CI: 1.31, 3.87) for women and 1.51 (95% CI: 1.07, 2.13), 1.59 (95% CI: 1.15, 2.20), and 1.52 (95% CI: 1.10, 2.09) for men. After stratification by smoking status, associations were observed in each smoking group for women, while those in men were weaker and less consistent. Similar results were obtained for forced vital capacity. This analysis indicates an association between lung function and incident coronary heart disease that may be stronger in women than in men.