MR-IMAGING OF THE DEVELOPING HUMAN BRAIN .2. POSTNATAL-DEVELOPMENT
MR-IMAGING OF THE DEVELOPING HUMAN BRAIN .2. POSTNATAL-DEVELOPMENT
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DOI：
10.1148/radiographics.13.3.8316668
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发表时间：
1993-05-01
期刊：
影响因子：
5.5
通讯作者：
SOILA, K
中科院分区：
文献类型：
--
作者：
BALLESTEROS, MC;HANSEN, PE;SOILA, K
回顾性研究了新生儿和24个月以下婴儿大脑的体内磁共振（MR）图像，以评估大脑的正常成熟模式。注意到各种脑结构的髓鞘形成和胼胝体的发育的顺序变化。在出生时和出生后的前4-6个月，灰质和白色物质的信号强度与成人大脑中所见的信号强度相反，在T1加权图像上，白色物质的信号强度低于灰质的信号强度，而在T2加权图像上高于灰质的信号强度。随着年龄的增长，白色物质在T1加权像上显示信号强度逐渐增加。在T2加权像上，高信号强度的无髓鞘白色物质逐渐转变为信号强度低于灰质的有髓鞘白色物质。出生时，胼胝体相对于白色物质是等信号的，并且信号强度逐渐增加，因此在8个月大时，胼胝体具有与成人相同的外观。熟悉MR成像所见的正常髓鞘形成的时间序列有助于诊断涉及白色物质的病理过程。
In vivo magnetic resonance (MR) images of the brain in neonates and infants up to 24 months of age were retrospectively studied to evaluate normal maturation patterns in the brain. Sequential changes in myelination of various brain structures and development of the corpus callosum were noted. At birth and for the first 4-6 months of life, signal intensities of gray and white matter are the reverse of those seen in an adult brain, with the signal intensity of white matter being lower than that of gray matter on T1-weighted images and higher than that of gray matter on T2-weighted images. With advancing age, white matter shows a progressive increase in signal intensity on T1-weighted images. On T2-weighted images, high-signal-intensity unmyelinated white matter progressively changes to myelinated white matter of a signal intensity lower than that of gray matter. At birth, the corpus callosum is isointense relative to white matter and progressively increases in signal intensity, so that at age 8 months the corpus callosum has an appearance identical to that of an adult. Familiarity with the temporal sequence of normal myelination as seen with MR imaging is helpful in the diagnosis of pathologic processes involving white matter.