Clinical applications of musculoskeletal tissue engineering.
Clinical applications of musculoskeletal tissue engineering.
复制标题
肌肉骨骼组织工程的临床应用。
DOI：
10.1093/bmb/ldn016
复制
发表时间：
2008
影响因子：
6.7
通讯作者：
K. Shakesheff
中科院分区：
文献类型：
--
作者：
S. Roberts;D. Howard;L. Buttery;K. Shakesheff
背景
当前用于修复肌肉骨骼系统的手术技术通常会受到材料（例如用于修复的移植物）的可用性、质量和数量的限制。这导致了基于组织工程和再生医学的新型干预方法的探索和发展。
数据来源
这篇综述总结了肌肉骨骼组织工程领域的成功和研究。这是基于广泛的文献检索和作者正在进行的基础研究。
意见一致的领域
由于某些手术技术的限制和使用限制，需要新的手术来修复和再生受损组织。
争议领域
细胞类型的选择在组织工程领域引起了许多争论。然而，人们普遍认为，目前只有自体原代/成体干细胞适合移植，直到胚胎干细胞存在优化的分化和选择方案。
生长点
利用组织工程构建体进行骨和软骨修复的临床病例的当前结果为这些技术的改进提供了见解，从而使治疗变得越来越可行。
及时开展研究的领域
需要更好地理解支架和细胞群整合到靶组织中。这应该提供影响支架制造程序和细胞选择的重要信息。
BACKGROUND
Current surgical techniques for the repair of the musculoskeletal system can be often limited by the availability, quality and quantity of materials, such as grafts to effect repair. This has led to the exploration and development of novel methods of intervention based on tissue engineering and regenerative medicine.
SOURCE OF DATA
This review summarizes the successes and investigations which are happening to date in the field of musculoskeletal tissue engineering. This is based on an extensive literature search and through basic research being performed by the authors.
AREAS OF AGREEMENT
Due to the constraints surrounding certain surgical techniques and restrictions on their use, novel procedures are required for the repair and regeneration of damaged tissues.
AREAS OF CONTROVERSY
The choice of cell type has caused much debate within the tissue-engineering field. However it is widely accepted that currently only autologous primary/adult stem cells are fit for transplantation, until such times that optimized differentiation and selection protocols exist for embryonic stem cells.
GROWING POINTS
The current results of the clinical cases utilizing tissue engineered constructs for bone and cartilage repair provide insights for improvement of these techniques thus allowing treatments to become increasingly viable.
AREAS TIMELY FOR DEVELOPING RESEARCH
There is a need to better understand the integration of scaffolds and cell populations into the target tissue. This should provide vital information influencing scaffold manufacturing procedures and cell selection.
影响因子：
3.7
作者：
Johnstone, B;Hering, TM;Yoo, JU
通讯作者：
Yoo, JU