The neural circuit for touch sensitivity in Caenorhabditis elegans
The neural circuit for touch sensitivity in Caenorhabditis elegans
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DOI：
10.1523/jneurosci.05-04-00956.1985
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发表时间：
1985-04
期刊：
影响因子：
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通讯作者：
M. Chalfie;J. Sulston;J. White;E. Southgate;J. Thomson;S. Brenner
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文献类型：
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作者：
M. Chalfie;J. Sulston;J. White;E. Southgate;J. Thomson;S. Brenner
秀丽线虫触觉运动的神经通路包括6个触觉感受器、5对中间神经元和69个运动神经元。这些细胞之间的突触关系已从连续切片电子显微镜重建中推断出来，并通过观察动物在激光显微手术选择性杀死细胞前体后的行为来评估细胞的作用。这一分析表明，触摸介导的前部触摸运动有两条途径(通过AVD和AVB中间神经元)，而后部触摸有一条单一途径(通过PVC中间神经元)。随着动物的成熟，前部触摸回路会以两种方式发生变化。首先，当三个前部的触觉细胞通过缝隙连接连接起来时，触觉细胞的神经网络就形成了。其次，在先前存在的AVD途径的基础上增加了AVB途径。触觉细胞还与许多可能不参与运动产生的细胞突触。这种突触表明，对这些受体的刺激可能会改变一些行为。
The neural pathways for touch-induced movement in Caenorhabditis elegans contain six touch receptors, five pairs of interneurons, and 69 motor neurons. The synaptic relationships among these cells have been deduced from reconstructions from serial section electron micrographs, and the roles of the cells were assessed by examining the behavior of animals after selective killing of precursors of the cells by laser microsurgery. This analysis revealed that there are two pathways for touch-mediated movement for anterior touch (through the AVD and AVB interneurons) and a single pathway for posterior touch (via the PVC interneurons). The anterior touch circuitry changes in two ways as the animal matures. First, there is the formation of a neural network of touch cells as the three anterior touch cells become coupled by gap junctions. Second, there is the addition of the AVB pathway to the pre- existing AVD pathway. The touch cells also synapse onto many cells that are probably not involved in the generation of movement. Such synapses suggest that stimulation of these receptors may modify a number of behaviors.