Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 Danish adults
Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 Danish adults
复制标题
DOI：
10.1136/gut.52.2.186
复制
发表时间：
2003-02-01
期刊：
影响因子：
24.5
通讯作者：
Andersen, L
中科院分区：
文献类型：
--
作者：
Rosenstock, S;Jorgensen, T;Andersen, L
背景：之前没有基于人群的前瞻性队列研究评估包括幽门螺杆菌感染在内的多种危险因素对消化性溃疡病 (PUD) 发病率的影响。目的：识别 PUD 的危险因素并估计其对溃疡发病率的相对影响。受试者：随机抽取 2416 名无 PU 病史的丹麦成年人。方法：样本成员于 1982 年和 1994 年进行访谈。观察期内诊断的 PU 通过医疗记录进行验证。有关心理社会因素、生活方式和药物治疗的信息是从研究开始时填写的调查问卷中获得的。通过 ELISA 测定幽门螺杆菌感染状况。结果：PUD 的主要危险因素是幽门螺杆菌感染（比值比 4.3（95% 置信区间 2.2；8.3））、吸烟（3.8（1.7；9.8））和使用小型镇静剂（3.0（1.4；6.6））。摄入非类固醇抗炎药并不影响PUD的发生率（0.4（0.1；2.3））。在幽门螺杆菌抗体增加的人群中，吸烟 (12.7 (2.8; 56.8)) 和摄入烈酒 (2.4 (1.1; 5.4)) 会增加 PUD 的风险，而适度的休闲时间体力活动 (0.3 (0.2; 0.7)) 可预防 PUD。 结论：吸烟和幽门螺杆菌感染是丹麦成人 PUD 的主要危险因素。体力活动可以预防幽门螺杆菌感染者预防 PUD。
Background: No population based prospective cohort study has previously assessed the impact of multiple risk factors, including Helicobacter pylori infection, on the incidence of peptic ulcer disease (PUD).Aims: To identify risk factors for PUD and estimate their relative impact on ulcer incidence.Subjects: Random sample of 2416 Danish adults with no history of PU.Methods: Sample members were interviewed in 1982 and 1994. PUs diagnosed within the observation period were verified through medical records. Information on psychosocial factors, lifestyle practices, and medication was obtained from a questionnaire completed at study entry. H pylori infection status was determined by ELISA.Results: The main risk factors for PUD were H pylori infection (odds ratio 4.3 (95% confidence interval 2.2; 8.3)), tobacco smoking (3.8 (1.7; 9.8)), and use of minor tranquillisers (3.0 (1.4; 6.6)). Intake non-steroid anti-inflammatory drugs did not affect the incidence of PUD (0.4 (0.1; 2.3)). In those with increased antibodies to H pylori tobacco smoking (12.7 (2.8; 56.8)) and intake of spirits (2.4 (1.1; 5.4)) increased the risk of PUD whereas moderate leisure time physical activity (0.3 (0.2; 0.7)) protected against PUD.Conclusions: Tobacco smoking and H pylori infection are the main risk factors for PUD in Danish adults. Physical activity may protect against PUD in those infected with H pylori.