The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study.
The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study.
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DOI：
10.1007/s10194-006-0281-7
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发表时间：
2006-04-01
期刊：
影响因子：
--
通讯作者：
Zwart, John-Anker
中科院分区：
文献类型：
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作者：
Hagen, Knut;Pettersen, Elin;Zwart, John-Anker
儿茶酚-O-甲基转移酶（COMT）基因含有一种功能性多态性，Val 158 Met，已被发现会影响人类的疼痛感知，一项研究发现，偏头痛在具有瓦尔/瓦尔多态性的人中发生的可能性较小。在1995-97 Nord-Trondelag Health（HUNT）研究中，在2451例随机样本中评估了Val 158 Met多态性与头痛之间的关联。Val 158 Met多态性与偏头痛之间没有关联。在女性中，非偏头痛性头痛的患病率在瓦尔/瓦尔基因型个体中低于其他基因型个体（26.2%对33.6%，p = 0.04）。非偏头痛性头痛在携带瓦尔/瓦尔基因型的妇女中较少发生，这可能是一个偶然的发现，但应在进一步的研究中进行调查。
The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception, and one study has found that migraine was less likely among those with the Val/Val polymorphism. In the 1995-97 Nord-Trondelag Health (HUNT) Study, the association between the Val158Met polymorphism and headache was evaluated in a random sample of 2451 individuals. No association between Val158Met polymorphism and migraine was found. Among women, a lower prevalence of non-migrainous headache was found among individuals with the Val/Val genotype than among those with other genotypes (26.2% vs. 33.6%, p = 0.04). That non-migrainous headache was less likely among women with the Val/Val genotype may be an incidental finding, but should be investigated in further studies.