CYTOKINES AS MODULATORS OF THE HYPOTHALAMUS PITUITARY-ADRENAL AXIS
CYTOKINES AS MODULATORS OF THE HYPOTHALAMUS PITUITARY-ADRENAL AXIS
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DOI：
10.1016/0960-0760(91)90284-c
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发表时间：
1991-01-01
影响因子：
4.1
通讯作者：
KABIERSCH, A
中科院分区：
文献类型：
--
作者：
BESEDOVSKY, HO;DELREY, A;KABIERSCH, A
下丘脑-垂体-肾上腺(HPA)轴在某些免疫、炎症和肿瘤过程中受到刺激。IL-1是一种重要的免疫衍生细胞因子，介导对这一轴的刺激，尽管不是唯一的。我们比较了具有多种生物学作用的细胞因子IL-1、IL-6和肿瘤坏死因子(TNF)刺激自由活动大鼠ACTH和皮质酮产生的相对效力。虽然三种细胞因子都能刺激HPA轴，但IL-1的作用最强。IL-1的这种作用也存在于新生期，此时啮齿类动物的HPA轴对急性应激的反应减弱。结果支持免疫-HPA轴回路的存在。讨论了该回路的生物学意义和临床意义。
The hypothalamus-pituitary-adrenal (HPA) axis is stimulated during the course of certain immune, inflammatory and neoplastic processes. IL-1 is an important immunologically derived cytokine mediating the stimulation of this axis, although not the only one. We have compared the relative potencies of the cytokines IL-1, IL-6 and tumor necrosis factor (TNF), which share several biological actions, for stimulating ACTH and corticosterone output in freely-moving rats. Although all three cytokines can stimulate the HPA axis, IL-1 was the most potent. This effect of IL-1 was also present during the neonatal period, when the response of the HPA axis to acute stress is reduced in rodents. The results support the existence of an immune-HPA axis circuit. The biological and clinical relevance of this circuit is discussed.