[Effect of the combination of cisplatin and peplomycin on Ehrlich ascites carcinoma and on head and neck squamous cell carcinoma transplanted to nude mice].
[Effect of the combination of cisplatin and peplomycin on Ehrlich ascites carcinoma and on head and neck squamous cell carcinoma transplanted to nude mice].
复制标题
顺铂联合培普霉素对艾氏腹水癌及头颈鳞癌裸鼠移植瘤的影响
DOI：
--
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
S. Mashino
中科院分区：
文献类型：
--
作者：
S. Mashino
为了开发顺铂（CPDD）和佩普霉素（PEP）的最佳联合用药方案，对联合用药进行了基础研究。在实验1中，使用已知对顺铂和培普霉素均敏感的艾利希腹水癌作为实验肿瘤。将移植有这种实验性癌症的六周龄雄性ICR小鼠分为35组：分别给予8、4或2mg/kg顺铂，或单独给予32、16或8mg/kg培洛霉素的组，或与顺铂作为前药或培洛霉素作为前药或两者同时给药的组，对照组和完整对照组。两种药物均通过腹腔内一次性注射给药。以平均生存时间和中位生存时间作为评价药效的参数。实验二采用裸鼠移植的头颈部鳞状细胞癌作为实验肿瘤。药物剂量为实验1的中间剂量；即顺铂4mg/kgr和培普霉素16mg/kg。两种药物均通过腹腔内一次性注射给药。将小鼠分为4组：对照组、单独接受培洛霉素的组、单独接受顺铂的组以及接受两种药物联合的组。通过各组肿瘤体积的变化来评价药物的抗肿瘤作用。结果表明以下结论。 1.在实验1中，CPDD和PEP的组合被证明对一半以上的治疗组产生协同效应。发现CPDD作为前药给药比其他两种给药顺序更有效且毒性更小，其与PEP作为前药治疗组的结果差异具有统计学意义。2．在实验2中，联合治疗组的抗肿瘤效果最高，通过统计分析证实，两种药物联合给药获得了协同效应。 3.从药效学、细胞动力学和DNA修复三个角度讨论了联合用药所观察到的协同作用机制；最后一个似乎是最有可能的机制。 4. 从这些临床前研究的结果和协同作用机制来看，CPDD 作为先行用药似乎是理想的用药顺序。
For the purpose of developing the optimal combination regimen with Cisplatin (CPDD) and Peplomycin (PEP), fundamental studies of the combination were made. In the experiment No. 1, Ehrlich ascites carcinoma, known to be sensitive to both cisplatin and peplomycin, was used as the experimental tumor. Six-week-old, male ICR mice, transplanted with this experimental carcinoma, were divided into 35 groups: the groups dosed with 8, 4 or 2mg/kg of cisplatinum, or 32, 16 or 8mg/kg of peplomycin alone, respectively, or in combination, with cisplatinum as the preceding medication or peplomycin as the preceding medication or both administered simultaneously, a control group, and an intact control group. Both drugs were administratered intraperitoneally by one-shot injection. The mean survival time and median survival time were used as parameters for the evaluation of drug effect. In the experiment No. 2, head and neck squamous cell carcinoma transplanted to nude mice was used as the experimental tumor. The doses of the drugs were the intermediate of those applied in the experiment No. 1; that is, cisplatin 4mg/kgr and peplomycin 16mg/kg. Both drugs were administered intraperitoneally by one-shot injection. The mice were divided into 4 groups: control group, a group receiving peplomycin alone, a group receiving cisplatin alone and a group receiving the combination of the two drugs. The antitumor effects of the drugs were evaluated by the changes in the volume of the tumor in each group. The results indicated following conclusions. 1. In the experiment No. 1, the combination of CPDD and PEP proved to exert a synergistic effect on more than half of the so treated groups. The administration of CPDD as the preceding medication was found to be more effective but less toxic than the other two administration sequence, and its difference from the findings in the group treated with PEP as the preceding medication was of statistical significances.2. In the experiment No. 2, the antitumor effects were highest in the group of combination treatment, and it was confirmed by the statistical analysis that the synergistic effects were obtained by the combined administration of both drugs. 3. The mechanism of the observed synergism in these combined administration was discussed from following three viewpoints: pharmacodynamic, cell kinetic and DNA repair; and the last seemed to be of the most probable mechanism. 4. From the findings in these preclinical studies and the mechanism of the synergism, the administration of CPDD as the preceding medication seemed to be the desirable medication sequence.
先前治疗过的头颈癌的顺铂疗法：西南肿瘤学组的每月两剂门诊治疗方案。
DOI：
10.1002/mpo.2950080303
发表时间：
1980
期刊：
Medical and pediatric oncology
影响因子：
--
作者：
Panettiere,FJ;Lehane,D;Fletcher,WS;Stephens,R;Rivkin,S;McCracken,JD
通讯作者：
McCracken,JD
顺铂对小鼠纤维肉瘤细胞的体内细胞周期阶段优先杀伤。
DOI：
--
发表时间：
1981
期刊：
Cancer treatment reports
影响因子：
--
作者：
Sigdestad,CP;Grdina,DJ
通讯作者：
Grdina,DJ