Vitamin D: An Evidence-Based Review
Vitamin D: An Evidence-Based Review
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DOI：
10.3122/jabfm.2009.06.090037
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发表时间：
2009-11-01
影响因子：
2.9
通讯作者：
Schrager, Sarina
中科院分区：
文献类型：
--
作者：
Kulie, Teresa;Groff, Amy;Schrager, Sarina
维生素D是一种脂溶维生素，在骨骼新陈代谢中发挥着重要作用，似乎具有一些抗炎和免疫调节特性。此外，最近的流行病学研究观察到低维生素D水平与多种疾病状态之间的关系。低维生素D水平与总体和心血管死亡率、癌症发病率和死亡率以及多发性硬化症等自身免疫性疾病的增加有关。虽然众所周知，随着人们年龄的增长，维生素D和钙的结合对于保持骨密度是必要的，但维生素D也可能是老年人跌倒的独立危险因素。美国医师协会的新建议解决了母乳喂养新生儿的补充需求，并提出了许多关于哺乳期间母亲补充的作用的问题。不幸的是，几乎没有证据指导临床医生何时筛查维生素D缺乏症或有效的治疗选择。(J am Board Fam Med 2009；22：698-706。)
Vitamin D is a fat-soluble vitamin that plays an important role in bone metabolism and seems to have some anti-inflammatory and immune-modulating properties. In addition, recent epidemiologic studies have observed relationships between low vitamin D levels and multiple disease states. Low vitamin D levels are associated with increased overall and cardiovascular mortality, cancer incidence and mortality, and autoimmune diseases such as multiple sclerosis. Although it is well known that the combination of vitamin D and calcium is necessary to maintain bone density as people age, vitamin D may also be an independent risk factor for falls among the elderly. New recommendations from the Association of American Physicians address the need for supplementation in breastfed newborns and many questions are raised regarding the role of maternal supplementation during lactation. Unfortunately, little evidence guides clinicians on when to screen for vitamin D deficiency or effective treatment options. (J Am Board Fam Med 2009; 22: 698-706.)