Occurrence of palytoxin-group toxins in seafood and future strategies to complement the present state of the art
Occurrence of palytoxin-group toxins in seafood and future strategies to complement the present state of the art
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DOI：
10.1016/j.toxicon.2010.11.014
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发表时间：
2011-03-01
期刊：
影响因子：
2.8
通讯作者：
Diogene, Jorge
中科院分区：
文献类型：
--
作者：
Aligizaki, Katerina;Katikou, Panagiota;Diogene, Jorge
海产品中的海葵毒素（Plytoxin，PlTX）和类海葵毒素（Plytoxin-like，PlTX-like）化合物近年来引起了科学界的关注。Ostreopsis属的致病性甲藻的记录数量的不断增加以及该属的大的空间扩展导致了对用于确定PlTX存在和毒性的方法的优化的研究的加强。在这种情况下，识别可能含有PlTX的海鲜物种是保护公众健康的一个重要问题。本文综述了世界范围内海产品中类PlTX化合物的发生情况，并讨论了未来的潜在策略。据报道，PlTX存在于多种鱼类、甲壳类动物、软体动物和棘皮动物中。有一次，在淡水河豚鱼中发现了PlTX，而所有其他PlTX记录都是指海洋物种，并且记录在北纬43度至南纬15度之间的纬度。海产品中的PlTX测定依赖于不同的方法（主要是LC-MS，小鼠生物测定和溶血中和测定），这些方法随着时间的推移而发展。未来的建议包括在已经记录了PlTX的物种和地区系统地筛查PlTX，实施最新的方法。(C)2010爱思唯尔有限公司版权所有。
Palytoxin (PlTX) and palytoxin-like (PlTX-like) compounds in seafood have been raising scientific concern in the last years. The constant increase in record numbers of the causative dinoflagellates of the genus Ostreopsis together with the large spatial expansion of this genus has led to intensification of research towards optimization of methods for determination of PlTX presence and toxicity. In this context, identification of seafood species which could possibly contain PlTXs constitutes an important issue for public health protection. In the present paper, worldwide occurrence of PlTX-like compounds in seafood is reviewed, while potential future strategies are discussed. PlTX has been reported to be present in several species of fish, crustaceans, molluscs and echinoderms. In one occasion, PlTX has been identified in freshwater puffer fish whereas all other records of PlTXs refer to marine species and have been recorded in latitudes approximately between 43 degrees N and 15 S. PlTX determination in seafood has relied on different methodologies (mainly LC-MS, mouse bioassay and hemolysis neutralization assay) that have evolved over time. Future recommendations include systematic screening of PlTX in those species and areas where PlTX has already been recorded implementing updated methodologies. (C) 2010 Elsevier Ltd. All rights reserved.