Phomopsolides and Related Compounds from the Alga-associated Fungus, Penicillium clavigerum
Phomopsolides and Related Compounds from the Alga-associated Fungus, Penicillium clavigerum
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DOI：
10.1177/1934578x1400900126
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发表时间：
2014-01
影响因子：
1.8
通讯作者：
A. Stierle;D. Stierle;G. Mitman;S. Snyder;C. Antczak;H. Djaballah
中科院分区：
文献类型：
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作者：
A. Stierle;D. Stierle;G. Mitman;S. Snyder;C. Antczak;H. Djaballah
在过去的十五年里，我们研究了极端真菌的次级代谢产物从伯克利坑，一个废弃的酸性矿山废水湖。与耐酸真菌相关的真菌也从坑中收获。从绿色小球藻中分离到一株棒状青霉（PenicilliumclavigerumDemelius）。在培养中，它产生已知的化合物phomfuranone（1）、棒曲霉素（2）、二甲基苯酞（3）和（4）、phomopsolide A（5）、phomopsolide C（6）、phomopsolide B（7）、phomopsolide E（8）、phomopsolide F（9）和phompyrone（10）以及新化合物berkbenzofuran thioester（11）。化合物5和6是特异性和已建立的人癌细胞系的有效抑制剂（IC 50 < 10 μM）。
For the past fifteen years we have studied the secondary metabolites of extremophilic fungi from the Berkeley Pit, an abandoned acid mine waste lake. Fungi associated with an acid-tolerant alga have also been harvested from the Pit. Penicillium clavigerum Demelius was isolated from the green alga Chlorella vulgaris Beyerinck [Beijerinck]. In culture it produced the known compounds phomfuranone (1), patulin (2), dimethylphthalides (3) and (4), phomopsolide A (5), phomopsolide C (6), phomopsolide B (7), phomopsolide E (8), phomopsolide F (9), and phompyrone (10) and the new compound berkbenzofuran thioester (11). Compounds 5 and 6 were potent inhibitors (IC50 < 10 μM) of specific and established human cancer cell lines.