Influence of social network on occurrence of dementia: a community-based longitudinal study
Influence of social network on occurrence of dementia: a community-based longitudinal study
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DOI：
10.1016/s0140-6736(00)02113-9
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发表时间：
2000-04-15
期刊：
影响因子：
168.9
通讯作者：
Winblad, B
中科院分区：
文献类型：
--
作者：
Fratiglioni, L;Wang, HX;Winblad, B
背景：关于社会关系对痴呆症发展的影响的数据很少。本研究探讨是否单一的社会网络组件和不同程度的社会连接影响痴呆incidence.Methods一个以社区为基础的队列的1203非痴呆症的人，住在家里的Kungsholmen区的斯德哥尔摩，瑞典，谁有良好的认知，平均为期3年。根据医学和心理学资料，根据《精神疾病诊断和统计手册》第三版修订本的标准，对176例患者进行了痴呆诊断。在基线时，由经过培训的护士通过个人访谈获得社会网络信息。协变量包括在分析中的年龄，性别，教育，认知和功能状态，抑郁症状，和vascular diseases.Findings这些人独自生活，那些没有任何密切的社会关系，都有一个调整后的相对风险为1.5（95%CI 1.0-2.1和1.0-2.4，分别）发展成痴呆症。与已婚者和某人一起生活相比，单身者和独居者的调整相对风险为1.9（95%CI 1.2-3.1）。与网络资源的不频繁接触不会增加疾病的风险，如果这种接触是令人满意的。当所有组成部分结合在一个指数，一个穷人或有限的社会网络增加痴呆症的风险60%（95%CI 1.2-2.1），和一个显着的梯度被发现的四个度的社会连接（p=0.0009）。确认这一发现和进一步的调查，以澄清机制是值得的，因为预防的影响。
Background Few data are available on the effect of social ties on dementia development. This study explored whether single social network components and different degrees of the social connections affect dementia incidence.Methods A community-based cohort of 1203 non-demented people, living at home in the Kungsholmen district of Stockholm, Sweden, and who had good cognition, was followed for an average period of 3 years. On the basis of medical and psychological data, 176 patients were diagnosed with dementia according to the criteria of the third edition revision of the Diagnostic and Statistical Manual of Mental Disorders. Information on social network was obtained by personal interview by trained nurses at baseline. The covariates included in the analysis were age, sex, education, cognitive and functional status, depressive symptoms, and vascular diseases.Findings Those individuals living alone, and those without any close social ties, both had an adjusted relative risk for developing dementia of 1.5 (95% CI 1.0-2.1 and 1.0-2.4, respectively). Compared with married people living with someone, single people and those living alone had an adjusted relative risk of 1.9 (95% CI 1.2-3.1). Infrequent contacts with network resources did not increase the risk of the disease if such contacts were experienced as satisfying. When all components were combined in an index, a poor or limited social network increased the risk of dementia by 60% (95% CI 1.2-2.1), and a significant gradient was found for the four degrees of social connections (p=0.0009).Interpretation An extensive social network seems to protect against dementia. Confirmation of this finding and further investigation to clarify the mechanisms are worthwhile due to the implications for prevention.