Mice Develop Efficient Strategies for Foraging and Navigation Using Complex Natural Stimuli.
Mice Develop Efficient Strategies for Foraging and Navigation Using Complex Natural Stimuli.
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DOI：
10.1016/j.cub.2016.03.040
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发表时间：
2016-05-23
期刊：
影响因子：
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通讯作者：
Murthy VN
中科院分区：
文献类型：
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作者：
Gire DH;Kapoor V;Arrighi-Allisan A;Seminara A;Murthy VN
在自然行为过程中在多种决策策略之间转换的能力使动物能够在灵活性和效率之间取得平衡。我们研究了小鼠的气味引导导航，以了解在复杂的自然行为过程中如何平衡决策策略。小鼠在开放的场地中利用自然波动的空气气味线索导航到气味源，因为它们的位置被实时精确记录。当小鼠对源位置的先前经验有限时，它们的搜索行为与梯度上升算法一致，该算法利用羽流中的方向线索导航到气味源。梯度攀爬是有效的，因为竞技场的大小允许动物主要在气味羽流内进行搜索，并频繁接触气味。随着经验的增加，小鼠将其策略从这种灵活的、感官驱动的搜索行为转变为更有效、更刻板的觅食方法，这种方法对气味羽流的反应几乎没有变化。这项研究表明，小鼠在动态自然刺激引导的复杂行为中利用先验知识自适应地平衡灵活性和效率。
The ability to shift between multiple decision-making strategies during natural behavior allows animals to strike a balance between flexibility and efficiency. We investigated odor-guided navigation by mice to understand how decision making strategies are balanced during a complex natural behavior. Mice navigated to odor sources in an open arena using naturally fluctuating airborne odor cues as their positions were recorded precisely in real time. When mice had limited prior experience of source locations, their search behavior was consistent with a gradient ascent algorithm that utilized directional cues in the plume to navigate to the odor source. Gradient climbing was effective because the arena size allowed animals to conduct their search mainly within the odor plume, with frequent odor contacts. With increased experience, mice shifted their strategy from this flexible, sensory-driven search behavior to a more efficient and stereotyped foraging approach that varied little in response to odor plumes. This study demonstrates that mice use prior knowledge to adaptively balance flexibility and efficiency during complex behavior guided by dynamic natural stimuli.