Studies in Carcinogenesis. XII. Effect of the Basic Fraction of Creosote Oil on the Production of Tumors in Mice By Chemical Carcinogens
Studies in Carcinogenesis. XII. Effect of the Basic Fraction of Creosote Oil on the Production of Tumors in Mice By Chemical Carcinogens
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致癌作用研究。
DOI：
10.1093/jnci/1.1.45
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发表时间：
1940
期刊：
影响因子：
--
通讯作者：
A. Perrault
中科院分区：
文献类型：
--
作者：
Robert D. Sall;M. J. Shear;J. Leiter;A. Perrault
自从在伦敦的Kennaway实验室发现1，2，5，6-二苯并蒽的致癌活性和从煤焦油中分离出3，4-苯并芘以来，大量的注意力集中在单个烃上，而对粗焦油的兴趣已经下降。值得注意的是，虽然兔子被用于实验动物的恶性肿瘤的第一次生产煤焦油，它们甚至对大剂量的纯碳氢化合物也相当难治。(For文献，见剪切（7）。）除苯并芘外，煤焦油中的其他成分也可能在粗焦油的致癌作用中起作用，这一点在前面的一篇论文中已经讨论过。研究发现，杂酚油的某些部分似乎可以延缓苯并芘引起的小鼠皮肤肿瘤的产生，而碱性部分则似乎可以促进苯并芘的产生。在这些实验中，用非近交系的雌性白化病小鼠进行的实验中，用于绘画的苯溶液分别含有0.2%和0.05%的苯并芘。
Since the discovery of the carcinogenic activity of 1, 2, 5, 6-dibenzanthracene and the isolation of 3, 4-benzpyrene from coal tar, in Kennaway's laboratory in London, a great deal of attention has been focused on the individual hydrocarbons, while interest in the crude tars has declined. It is interesting to note that, whereas rabbits were employed in the first production of malignant tumors in experimental animals by coal tar, they are rather refractory even to large doses of the pure hydrocarbons.(For literature, see Shear (7).) The possibility that other constituents of coal tar besides benzpyrene may play a part in the carcinogenic action of the crude tar has been considered in a preceding paper (2). It was found that certain fractions of creosote oil appeared to retard the production of skin tumors in mice by benzpyrene, whereas the basic fraction appeared to promote it. In those experiments, performed with female albino mice not of inbred stock, the benzene solutions employed in the painting contained 0.2 and 0.05 percent, respectively, of benzpyrene.