Inflammation and atherosclerosis.
Inflammation and atherosclerosis.
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DOI：
10.1007/s11883-004-0102-x
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发表时间：
2004-03-01
影响因子：
5.8
通讯作者：
Bhatt, Deepak L
中科院分区：
文献类型：
--
作者：
Shishehbor, Mehdi H;Bhatt, Deepak L
炎症在动脉粥样硬化的所有阶段都起着关键作用，从泡沫细胞到斑块形成，再到破裂，最终形成血栓。从最近的基础和临床数据中获得的见解将炎症与动脉粥样硬化联系起来，已经产生了重要的诊断和预后信息。高敏感性c反应蛋白检测的低级别慢性炎症可预测未来急性冠状动脉综合征的风险，独立于传统心血管危险因素。此外，具有较高“炎症负担”的个体通过积极的降低风险治疗获得最大的绝对风险降低。炎症和动脉粥样硬化之间的联系为未来可能通过抑制炎症来减缓动脉粥样硬化进展的药物提供了新的途径。
Inflammation plays a pivotal role in all stages of atherogenesis, from foam cell to plaque formation to rupture and ultimately to thrombosis. Insight gained from recent basic and clinical data linking inflammation to atherosclerosis has yielded important diagnostic and prognostic information. Low-grade chronic inflammation as measured by high sensitivity C-reactive protein predicts future risk of acute coronary syndrome independent of traditional cardiovascular risk factors. In addition, individuals with higher "inflammatory burden" gain the largest absolute risk reduction with aggressive risk-lowering therapy. The link between inflammation and atherosclerosis provides a new venue for future pharmacologic agents that may slow the progression of atherosclerosis by inhibiting inflammation.