Genetic stretching factors in masseter muscle after orthognathic surgery
Genetic stretching factors in masseter muscle after orthognathic surgery
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DOI：
10.1016/j.bjoms.2012.11.009
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发表时间：
2013-09-01
影响因子：
1.8
通讯作者：
Harzer, Winfried
中科院分区：
文献类型：
--
作者：
Breuel, Wiebke;Krause, Micaela;Harzer, Winfried
高达30%的患者在正颌手术后复发，其中一个原因可能是咀嚼肌的神经肌肉适应不完全。下颌骨在矢状方向或垂直方向或两者上的移位导致这些肌肉的拉伸或压缩。本研究的目的是分析35例下颌骨后缩或多颌畸形（II类和III类）患者的拉伸因素。分别于术前和术后6个月取双侧咬肌组织标本。通过真实的时间聚合酶链反应（PCR）分析发育肌球蛋白重链MYH 3和MYH 8、快和慢MYH 1、2和7、以及环加氧酶（考克斯）2、叉头转录因子（FOX）O3 a、钙调神经磷酸酶和活化T细胞核因子（NFAT）lc（拉伸和再生特异性）。分析了Ⅱ、Ⅲ类错畸形与矢状面和垂直面测量ANB和ML-NL角的相关性，结果显示MYH 8（p <0.05）、MYH 1（p <0.05）和FOXO 3a（p <0.05）的数量差异有统计学意义。
Up to 30% of patients relapse after orthognathic operations, and one reason might be incomplete neuromuscular adaptation of the masticatory muscles. Displacement of the mandible in sagittal or vertical directions, or both, leads to stretching or compression of these muscles. The aim of this study was to analyse stretching factors in 35 patients with retrognathism or prognathism of the mandible (Classes II and HI). Tissue samples were taken from both sides of the masseter muscle (anterior and posterior) both before and 6 months after operation. Developmental rnyosin heavy chains MYH3 and MYH8, the fast and slow MYH 1, 2, and 7, and cyclo-oxygenase (COX) 2, forkhead transcription factor (FOX)O3a, calcineurin, and nuclear factor of activated T cells (NFAT) lc (stretching and regeneration-specific), were analysed by real time polymerase chain reaction (PCR). Correlations of Class II and III with sagittal and vertical cephalometric measurements ANB and ML-NL-angle were examined, and the results showed significant differences in amounts of MYH8 (p < 0.0 5), MYH1 (p < 0.0 5), and FOXO3a (p