Biological approaches for hypertrophic scars
Biological approaches for hypertrophic scars
复制标题
增生性疤痕的生物学方法
DOI：
10.1111/iwj.13286
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发表时间：
2019-12-20
影响因子：
3.1
通讯作者：
Fu Xiaobing
中科院分区：
文献类型：
--
作者：
Zhong Lingzhi;Li Meirong;Fu Xiaobing
瘢痕形成通常是皮肤创伤的病理结果。而增生性瘢痕（hypertrophic scars，HS）是人体严重创伤后常见的瘢痕。HS通常被认为是组织收缩和过度细胞外基质成分沉积的结果。肌成纤维细胞作为主要由成纤维细胞分化而来的效应细胞，在HS的病理生理过程中起着至关重要的作用。多种生长因子、炎性细胞因子参与了HS的发生过程。目前，随着对HS的深入探索和临床研究，各种创新有效的治疗方法不断涌现。本文综述了近年来HS分子机制的研究进展，并对HS病理生理特征的生物学检测方法进行了综述。并进一步展望了综合疗法可能更适合HS的治疗。
Scar formation is usually the pathological consequence of skin trauma. And hypertrophic scars (HSs) frequently occur in people after being injured deeply. HSs are unusually considered as the result of tissue contraction and excessive extracellular matrix component deposition. Myofibroblasts, as the effector cells, mainly differentiated from fibroblasts, play the crucial role in the pathophysiology of HSs. A number of growth factors, inflammatory cytokines involved in the process of HS occurrence. Currently, with in-depth exploration and clinical research of HSs, various creative and effective treatments budded. In here, we summarize the progress in the molecular mechanism of HSs, and review the available biotherapeutic methods for their pathophysiological characteristics. Additionally, we further prospected that the comprehensive therapy may be more suitable for HS treatment.