Topographic mapping in the retinotectal projection by means of complementary ligand and receptor gradients: a computer simulation study
Topographic mapping in the retinotectal projection by means of complementary ligand and receptor gradients: a computer simulation study
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DOI：
10.1006/jtbi.1998.0662
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发表时间：
1998-05-21
影响因子：
2
通讯作者：
Honda, H
中科院分区：
文献类型：
--
作者：
Honda, H
基于最近对视网膜表面受体密度(R)和顶盖表面配体密度(L)互补梯度的实验研究，并将受体梯度上的高点映射到配体梯度上的低点，反之亦然，建立了涉及视网膜轴突自动感知信号强度(R.L)和标准值(S)之间差异的伺服机制模型。基于该模型的计算机模拟显示了所需的视网膜轴突在顶盖上的二维地形图，并解释了在使用顶盖膜碎片组成的条纹对视网膜轴突进行条纹分析时观察到的视网膜轴突的三种奇怪行为：视网膜轴突受到配体物质的排斥行为，鼻轴突是否显示出对前盖和后盖物质的区域选择性，以及起源于具有梯度配体密度的条纹上连续变化的视网膜位置的轴突生长的突然转变。最后，我们提出了在人工梯度顶盖膜片断的条带分析中需要改进的地方。(C)1998年学术出版社有限公司。
Based on recent experimental studies of complementary gradients of receptor density (R) on the retinal surface and ligand density (L) on the tectal surface, and mapping of the high point on the receptor gradient to the low point on the ligand gradient and vice versa, the servomechanism model was constructed involving a mechanism for the retinal axon to reach its target automatically sensing a difference between the signal strength (R.L) and the standard value (S). Computer simulations based on the model demonstrated desired two-dimensional topographic mapping of the retinal axons on the tectum, and explained three strange behaviors of the retinal axons that had been observed in stripe assays for retinal axons using stripes composed of tectal membrane fragments: repulsive behaviors of the retinal axons by the ligand substances, uncertainty of the nasal axons whether or not they show regional selectivity between substances of anterior and posterior tecta, and abrupt transition of growth of the axons originating at continuously varied retinal positions on the stripes having graded ligand density. Finally we suggested what is to be improved in stripe assays with the artificial gradient of the tectal membrane fragments. (C) 1998 Academic Press Limited.