Allogeneic marrow transplantation for acute nonlymphoblastic leukemia after first relapse
Allogeneic marrow transplantation for acute nonlymphoblastic leukemia after first relapse
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同种异体骨髓移植治疗急性非淋巴细胞白血病首次复发后
DOI：
10.1182/blood.v61.5.949.bloodjournal615949
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发表时间：
1983
期刊：
影响因子：
20.3
通讯作者：
Thomas Ed
中科院分区：
文献类型：
--
作者：
Appelbaum Fr;R. Clift;Buckner Cd;P. Stewart;R. Storb;K. Sullivan;Thomas Ed
62例首次复发或第二次缓解的急性非淋巴细胞白血病患者接受hla匹配的兄弟姐妹的同种异体骨髓移植治疗。17例患者（第一组）在移植前未尝试再诱导缓解。在20例患者（第二组）中，移植前诱导第二次缓解的尝试均未成功；在25名患者（第三组）中，实现了第二次缓解。1组17例患者中有5例（29%），2组20例患者中有2例（10%），3组25例患者中有5例（20%）移植后2 - 6年无病存活。非白血病原因的早期死亡率在三组中相等，但移植后未尝试再诱导的患者白血病复发的风险较低（组1）。在复发的患者中，早期复发的患者（骨髓中原始细胞少于30%）似乎比早期复发的患者做得更好。第1组获得的结果与第二次或随后缓解的移植患者的结果一样好或更好。因此，对于首次缓解时未进行移植的急性非淋巴细胞白血病患者，移植的最佳时间似乎是在首次复发后尽快进行。
Sixty-two patients with acute nonlymphoblastic leukemia in first relapse or second remission were treated with allogeneic marrow transplantation from HLA-matched siblings. In 17 patients (group 1), no attempt at reinduction of remission was made prior to transplantation. In 20 patients (group 2), attempts at inducing a second remission prior to transplantation were unsuccessful; and in 25 patients (group 3), a second remission was achieved. Five of 17 patients (29%) in group 1, 2 of 20 (10%) in group 2, and 5 of 25 (20%) in group 3 are surviving disease-free 2–6 yr after grafting. Early mortality from nonleukemic causes was equal in the 3 groups, but the risk of recurrent leukemia after transplantation was less in patients transplanted without attempts at reinduction (group 1). Among patients transplanted in relapse, those in early relapse (less than 30% blast cells in the marrow) appeared to do better than patients in florid relapse. The results obtained in group 1 are as good as or better than those achieved in patients transplanted in second or subsequent remission. Thus, for patients with acute nonlymphoblastic leukemia not transplanted in first remission, the optimal time for transplantation would appear to be as soon as possible after the first relapse.
影响因子：
20.3
作者：
K. Rai;J. Holland;O. Glidewell;V. Weinberg;K. Brunner;JP Obrecht;H. Preisler;IW Nawabi;D. Pr
通讯作者：
K. Rai;J. Holland;O. Glidewell;V. Weinberg;K. Brunner;JP Obrecht;H. Preisler;IW Nawabi;D. Pr