Early effect of ApoE-epsilon 4 allele on cognitive results in a group of highly performing subjects: The EVA study
Early effect of ApoE-epsilon 4 allele on cognitive results in a group of highly performing subjects: The EVA study
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DOI：
10.1016/s0304-3940(96)13059-7
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发表时间：
1996-10-25
影响因子：
2.5
通讯作者：
Alperovitch, A
中科院分区：
文献类型：
--
作者：
Berr, C;Dufouil, C;Alperovitch, A
我们在1174名59-71岁的高功能志愿者中研究了载脂蛋白E（ApoE）等位基因和认知能力之间的关系。神经心理成套测验包括简易精神状态检查（MMSE）和9项测试，评估视觉注意力、文字记忆、视觉处理、逻辑推理、心理反应速度、视觉记忆、听觉注意力和文字流畅性。基因型中0个、1个和2个等位基因的比例分别为70.6%、21.4%和1.9%。等位基因E14与视觉注意力、精神敏捷性和MMSE评分较低显著相关。在最佳表现者亚组（MMSE评分高于25，n = 1028）中，所有关系持续存在。我们的研究结果表明，ApoE-104等位基因是早期与低正常认知表现的领域，而不是特别影响在亚临床痴呆发作。
We examined the association between apolipoprotein E (ApoE) epsilon 4 allele and cognitive performances in a population sample of 1174 high functioning volunteers aged 59-71 years. The neuropsychological battery included the Mini Mental State Examination (MMSE) and nine tests assessing visual attention, verbal memory, visual processing, logical reasoning, psychomotor rapidity, visual memory, auditory attention and verbal fluency. The ratio of genotypes with zero, one or two epsilon 4 alleles was 70.6%, 21.4% and 1.9%, respectively. The epsilon 4 allele was significantly associated with lower scores for visual attention, psychomotor rapidity and MMSE. In the best performer subgroup (MMSE score above 25, n = 1028), all relationships persisted. Our findings demonstrate that the ApoE-epsilon 4 allele is early associated with low normal cognitive performances in areas which are not specifically affected at the subclinical onset of dementia.