High myopia associated with retinopathy of prematurity is primarily lenticular
High myopia associated with retinopathy of prematurity is primarily lenticular
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DOI：
10.1016/j.jaapos.2004.12.018
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发表时间：
2005-04-01
期刊：
影响因子：
1.6
通讯作者：
Kaufman, LM
中科院分区：
文献类型：
--
作者：
Garcia-Valenzuela, E;Kaufman, LM
目的.通过与足月儿高度近视眼的比较，确定早产儿视网膜病变（ROP）中高度近视眼的屈光组成部分。该研究包括34例有ROP病史的患者的53只高度近视眼和37例足月患者的66只高度近视眼。测量包括屈光、角膜曲率和A扫描值，用于轴长、透镜厚度、透镜位置、前房深度、前段深度和透镜屈光度计算。与已发表的年龄匹配的足月正常对照组进行比较。ROP和足月眼的屈光度范围分别为-5.0至-20.75和-5.0至-22.0屈光度。对于ROP眼，增加的近视与透镜厚度和透镜屈光度最相关（P < 0.001），角膜陡度、眼轴长度和透镜中心更靠前的位置的影响较小。对于足月患者的近视眼，近视增加与眼轴长度高度相关（P < 0.001），透镜厚度和透镜屈光度增加的贡献较小。ROP眼的晶状体厚度/前房深度比比FT和正常眼高近50%。所有研究眼的眼前节深度非常相似。与ROP相关的高度近视在病理生理上与足月患者的高度近视不同。ROP眼的透镜厚度增加，伴随着较浅的前房深度和维持眼前节深度，类似于正常新生儿眼，这表明ROP导致高度近视的眼前节发育改变的机制。
Purpose. To determine which of the eye's refractive components are responsible for the high myopia in retinopathy of prematurity (ROP), as compared with highly myopic eyes in full-term patients.Methods. The study included 53 highly myopic eyes in 34 patients with a history of ROP, and 66 highly myopic eyes in 37 full-term patients. Measurements included refraction, keratometry, and A-scan values for axial length, lens thickness, lens position, anterior chamber depth, anterior segment depth, and lens power calculations. Comparisons were also made with published age-matched, full-term normal controls.Results. Refractions ranged from a spherical-equivalent of -5.0 to -20.75, and from -5.0 to -22.0 diopters in ROP and full-term eyes, respectively. For ROP eyes, increasing myopia was most associated with lens thickness,and lens power (P < 0.001), with lesser contributions from corneal steepness, axial length, and a more forward position of the lens's center. For the eyes with myopia in full-term patients, increasing myopia was highly associated with axial length (P < 0.001), with smaller contributions from increased lens thickness and lens power. ROP eyes had a lens-thickness/anterior-chamber-depth ratio almost 50% higher than FT and normative eyes. Anterior segment depth was remarkably similar in all eyes studied.Conclusions. High myopia associated with ROP appears pathophysiologically distinct from high myopia in full-term patients. The increased lens thickness seen in ROP eyes was accompanied by shallower anterior chamber depth and maintenance of the anterior segment depth, similar to the normal neonatal eye, suggesting a mechanism of altered anterior segment development in ROP leading to high myopia.