Analysis of Stereochemical Stability of Dynamic Chiral Molecules Using an Automated Microflow Measurement System
Analysis of Stereochemical Stability of Dynamic Chiral Molecules Using an Automated Microflow Measurement System
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使用自动微流测量系统分析动态手性分子的立体化学稳定性
DOI：
10.1021/acs.joc.1c00914
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Tomooka Katsuhiko
中科院分区：
文献类型：
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作者：
Igawa Kazunobu;Asano Shusaku;Yoshida Yuki;Kawasaki Yuuya;Tomooka Katsuhiko
建立了一套用于动态手性分子消旋反应动力学研究的自动化微流测量系统。由于其快速加热能力、用于控制短停留时间的高性能以及易于连接到HPLC系统以直接测量对映体纯度，该系统促进了在升高的温度下在几秒钟内快速外消旋化的分析。通过在宽温度范围内结合微流和普通批量测量实现了更精确的分析。
An automated microflow measurement system for the kinetic study of racemization of dynamic chiral molecules was developed. This system facilitated the analysis of fast racemization within several seconds at elevated temperatures owing to its rapid heating ability, high performance for controlling short residence times, and ease of connection to HPLC systems for direct measurement of the enantiomeric purity. A more precise analysis was realized by combination of microflow and common batch measurements over a broad range of temperatures.