The Neuropsychological Phenotype in Turner Syndrome
The Neuropsychological Phenotype in Turner Syndrome
复制标题
特纳综合征的神经心理学表型
DOI：
10.1016/s0010-9452(85)80004-6
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发表时间：
1985
期刊：
影响因子：
3.6
通讯作者：
D. Shucard
中科院分区：
文献类型：
--
作者：
B. Pennington;R. Heaton;P. Karzmark;M. G. Pendleton;R. Lehman;D. Shucard
大量研究表明，特纳综合症 (TS) 女性的表现智商 (PIQ) 显着下降，但这一发现的神经心理学解释仍不清楚。本研究解决了有关 TS 神经心理表型的以下问题：(1) TS 女性神经心理受损吗？ (2) 损伤是否偏向以及 (3) TS 个体的神经心理学表型的一致性如何？与之前的研究不同，本研究同时使用了正常和脑损伤的女性对照。所有受试者都接受了延长的 Halstead-Reitan 神经心理电池治疗。 TS 女性的神经心理功能总体水平明显低于正常人，但与脑损伤女性没有显着差异。然而，他们的损伤并没有被单侧化。他们的侧化发现模式与弥漫性和正常组中发现的相似，但与右侧或左侧单侧病变组显着不同。在视觉空间技能和长期记忆测试中发现了相当一致的缺陷，但 TS 个体的所有其他测试结果存在相当大的差异。该结果与最近的研究结果（Inglis 和 Lawson，1981）进行了讨论，即言语表现智商差异可能是女性偏侧脑功能障碍的不可靠指标。因此，TS 中 PIQ 的降低似乎并不主要表明右半球功能障碍，甚至可能不表明一致的潜在神经心理学表型。
Numerous studies have demonstrated a significant depression in performance IQ (PIQ) in Turner Syndrome (TS) females, but the neuropsychological interpretation of this finding remains unclear. The present study addressed the following questions regarding the neurospychological phenotype in TS: (1) Are TS women neuropsychologically impaired? (2) Is the impairment lateralized and (3) How consistent is the neuropsychological phenotype across TS individuals? Unlike previous studies, the present study utilized both normal and brain damaged female controls. All subjects were given an extended Halstead-Reitan neuropsychological battery.The TS females were significantly worse than normals but not significantly different from brain damaged females in their overall level of neuropsychological functioning. However, their impairment was not lateralized. Their pattern of lateralizing findings was similar to that found in the Diffuse and Normal groups, but significantly different from either the right or left unilateral lesion groups. Fairly consistent deficits were found on tests of visuospatial skills and long term memory, but there was considerable variability in all the other test findings among TS individuals. The results are discussed in relation to the recent findings (Inglis and Lawson, 1981) that verbal-performance IQ discrepancies may be unreliable indicators of lateralized cerebral dysfunction in females. Hence the depressed PIQ in TS appears not to indicate predominantly right hemisphere dysfunction and may not even indicate a consistent underlying neuropsychological phenotype.