Chinese medicine formula lingguizhugan decoction improves Beta-oxidation and metabolism of Fatty Acid in high-fat-diet-induced rat model of Fatty liver disease.
Chinese medicine formula lingguizhugan decoction improves Beta-oxidation and metabolism of Fatty Acid in high-fat-diet-induced rat model of Fatty liver disease.
复制标题
中药方苓桂术甘汤改善高脂饮食诱导的脂肪肝大鼠模型脂肪酸β氧化和代谢
DOI：
10.1155/2013/429738
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ji G
中科院分区：
文献类型：
--
作者：
Liu T;Yang LL;Zou L;Li DF;Wen HZ;Zheng PY;Xing LJ;Song HY;Tang XD;Ji G
苓桂术甘汤是一个经典的中医方剂，近年来被用于治疗肥胖和高脂血症，但苓桂术甘汤调节脂质代谢的相关机制尚不清楚。本研究旨在探讨LGZG对高脂饮食诱导的大鼠脂肪肝的治疗作用及其可能的作用机制。我们的研究结果表明，LGZG显着减轻HFD诱导的脂肪肝疾病，如体重，肝脏指数，附睾脂肪垫/体重比（EFP/BW），肝损伤和肝脏甘油三酯（TG），可能是通过提高血清甲状腺激素水平，改善β-氧化（通过调节TRβ1和CPT 1A的表达）、脂肪酸的代谢和转运（通过调节SREBP-1c、ACSL和ApoB 100的表达）。此外，通过对拆方的进一步研究，发现了该方中具有温阳利水作用的药物组合，并提出了LGZG常规作用的生物学基础。这项研究首次揭示了LGZG调节脂质代谢的机制。从经方常规功效的角度理解中医药的科学内涵是可行的。
Lingguizhugan decoction (LGZG), a classic traditional Chinese medicine (TCM) formula, has been used to treat obesity and hyperlipidemia in recent years, but the related mechanisms underlying the regulation of lipid metabolism by LGZG are not clear yet. Here, we reported the effectiveness and possible mechanisms of LGZG on rats with fatty liver disease induced by high-fat diet (HFD). Our results demonstrated that LGZG significantly attenuated HFD-induced fatty liver disease, as measured by body weight, liver index, epididymal fat pad-body weight ratio (EFP/BW), liver injury, and hepatic triglycerides (TG) probably through increasing serum thyroid hormone levels, improving beta-oxidation (via modulation of TRβ1 and CPT1A expression), metabolism and transport (through modulation of SREBP-1c, ACSL and ApoB100 expression) of fatty acid. In addition, we discovered the herbal combination with the properties of warming yang to relieve water retention in the formula and proposed the biological basis of LGZG conventional effect via further study on disassembled formula. This study, for the first time, revealed the mechanisms through which LGZG regulates lipid metabolism. Furthermore, our study suggested that it might be feasible to understand the scientific implications of TCM from the perspective of classic formulas' conventional efficacy.