Reverse use dependence of human ventricular repolarization by chronic oral sotalol in monophasic action potential recordings.
Reverse use dependence of human ventricular repolarization by chronic oral sotalol in monophasic action potential recordings.
复制标题
在单相动作电位记录中长期口服索他洛尔对人心室复极的反向使用依赖性。
DOI：
10.1016/s0002-9149(97)89159-x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
K. Shimomura
中科院分区：
文献类型：
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作者：
W. Shimizu;T. Kurita;K. Suyama;N. Aihara;S. Kamakura;K. Shimomura
索他洛尔（dl-索他洛尔）是一种III类药物，通过阻断延迟整流钾电流的快速激活成分来延长心室动作电位持续时间。一些III类药物（包括索他洛尔）延长动作电位时程的程度已被证明在短心室起搏周期长度（CL）下减弱（即，反向使用依赖性）。*施密特等人3最近使用单相动作电位（MAP）证明了人心室中静脉注射索他洛尔时动作电位持续时间的反向使用依赖性。然而，据报道，尽管与静脉注射索他洛尔后相比，索他洛尔的血清水平较低，但在长期口服索他洛尔治疗期间复极（QT间期）延长更为显著。4因此，本研究考察了长期口服索他洛尔对人心室动作电位时程的反向使用依赖性。
S otalol (dl-sotalol), a class III agent, prolongs the ventricular action potential duration by blocking the rapidly activating component of the delayed rectifier potassium current.’The degree of lengthening of action potential duration by some class III drugs, including sotalol, has been shown to be attenuated at short ventricular paced cycle lengths (CL)(ie, reverse use dependence).* Schmitt et al3 recently used the monophasic action potential (MAP) to demonstrate the reverse use dependence of action potential duration with intravenous sotalol in the human ventricle. However, the prolongation of repolarization (QT interval) is reported to be more marked during chronic oral therapy with sotalol, despite lower serum levels of the drug compared with those after intravenous sotalol. 4 Therefore, this study examines the reverse use dependence of action potential duration by chronic oral sotalol in the human ventricle.