UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects.
UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects.
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DOI：
10.1111/php.12703
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发表时间：
2017-07
影响因子：
3.3
通讯作者：
Travers JB
中科院分区：
文献类型：
--
作者：
Fahy K;Liu L;Rapp CM;Borchers C;Bihl JC;Chen Y;Simman R;Travers JB
紫外线B辐射(UVB)对人体皮肤有深远的影响。关于UVB产生大量生物活性物质的能力已知很多，包括细胞因子和其他生物活性蛋白质、脂质介体和微型RNA。据推测，这些制剂在很大程度上要对UVB的影响负责，而UVB只在表皮中有轻微的吸收。然而，这些生物活性物质离开表皮的确切机制尚不清楚。本文综述了微泡颗粒(MVP)通过传递生物介体作为UVB信号转导介质的潜在作用。提供了新的数据，UVB处理人皮肤外植体也产生MVP。我们推测，UVB产生的MVP(UVB-MVP)可能具有传递角质形成细胞来源的生物活性物质的重要功能。此外，我们认为UVB-MVP的形成与脂质介质血小板活化因子有关。这一新途径有可能在药理学上被用来调节UVB效应。UVB通过脂质介质血小板活化因子(PAF)的参与产生微泡颗粒。这幅漫画描绘了UVB诱导活性氧物种(ROS)产生PAF激动剂，然后触发微泡颗粒释放的理论途径。这幅漫画还暗示了这一途径可以被调节的潜在靶点。
Ultraviolet B radiation (UVB) exerts profound effects on human skin. Much is known regarding the ability of UVB to generate a plethora of bioactive agents ranging from cytokines and other bioactive proteins, lipid mediators and micro-RNAs. It is presumed that these agents are in large part responsible for the effects of UVB, which only is absorbed appreciably in the epidermis. However, the exact mechanism by which these bioactive agents can leave the epidermis are as yet unclear. This review addresses the potential role of microvesicle particles (MVP) as UVB signaling agents through transmitting biologic mediators. New data is provided that UVB treatment of human skin explants also generates MVP production. We hypothesize that UVB production of MVPs (UVB-MVP) could serve this important function of transmitting keratinocyte-derived bioactive agents. Moreover, we propose that UVB-MVP formation involves the lipid mediator Platelet-activating factor. This novel pathway has the potential to be exploited pharmacologically to modulate UVB effects. UVB generates microvesicle particles through Involvement of the lipid mediator Platelet-activating Factor (PAF). The cartoon depicts theoretical pathway by which UVB-induced reactive oxygen species (ROS) which generate PAF agonists that then trigger microvesicle particle release. This cartoon also suggests potential targets by which this pathway can be modulated.