THE POLYPHYLETIC ORIGIN OF LABORATORY INBRED MICE AND THEIR RATE OF EVOLUTION
THE POLYPHYLETIC ORIGIN OF LABORATORY INBRED MICE AND THEIR RATE OF EVOLUTION
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DOI：
10.1111/j.1095-8312.1987.tb00288.x
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发表时间：
1987-01-01
影响因子：
1.9
通讯作者：
BULFIELD, G
中科院分区：
文献类型：
--
作者：
BONHOMME, F;GUENET, JL;BULFIELD, G
对标准近交系实验室品系小鼠的各种遗传成分的分析表明，复杂种小家鼠的几个分类单位对它们的遗传背景有贡献。这些实验室品系通常被认为是哺乳动物基因组的原型，因为它们的谱系已经知道了大约80年，它们被用来估计突变率和各种其他进化参数。如果要避免错误的解释，了解它们的起源是很重要的。它们是否具有可能存在于M.或者它们是不同基因组之间人工重组的产物？我们将根据不同的遗传系统来讨论这一点。
The analysis of various genetic components in the standared inbred laboratory strains of mice shows that several taxonomic units of the complex species Mus musculus have contributed to their genetic background. These laboratory lines are often taken as archetypes of the mammalian genome and since their genealogy is known for around 80 years they have been used to estimate mutation rates and various other evolutionary parameters. The knowledge of their origins is important if one is to avoid erroneous interpretations. Do they possess haplotypes that could have existed in natural populations of M. musculus domesticus or are they the fruit of artificial recombinations between divergent genomes? We discuss this in the light of various genetic systems.