Intrinsic Brain Network Abnormalities in Migraines without Aura Revealed in Resting-State fMRI
Intrinsic Brain Network Abnormalities in Migraines without Aura Revealed in Resting-State fMRI
复制标题
静息态功能磁共振成像揭示无先兆偏头痛的内在大脑网络异常
DOI：
10.1371/journal.pone.0052927
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发表时间：
2012-12-28
期刊：
影响因子：
3.7
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Xue, Ting;Yuan, Kai;Tian, Jie
背景：以往的研究已经在静息功能磁共振成像（fMRI）数据中定义了低频、空间一致的内在连接网络（ICN），它反映了不同脑区之间的功能相互作用。我们试图探索反复偏头痛发作是否以及如何影响内在的大脑连接，以及这些网络的活动如何与偏头痛的临床指标相关。方法/主要发现：对23例无先兆偏头痛（MwoA）患者和23例年龄和性别匹配的健康对照（HC）的静息状态fMRI数据进行独立成分分析（ICA），结合“双回归”技术，确定MwoA患者和HC之间三个重要的疼痛相关网络[默认模式网络（DMN），双侧中央执行网络（CEN），突出网络（SN）]的组间差异。与HC相比，MwoA患者在双侧CEN和SN内表现出异常的内在连通性，并且DMN和右侧CEN （rCEN）与脑岛皮质（一个参与疼痛处理的关键区域）之间的连通性更强。此外，DMN、rCEN和脑岛之间更强的连通性与偏头痛持续时间相关。结论：我们的研究结果可能为偏头痛作为一种影响大脑内在连接网络活动的疾病的特征提供新的见解。此外，这种异常可能是持续的中枢神经系统功能障碍的结果，反映了频繁持续的偏头痛发作造成的累积性脑损伤。
Background: Previous studies have defined low-frequency, spatially consistent intrinsic connectivity networks (ICN) in resting functional magnetic resonance imaging (fMRI) data which reflect functional interactions among distinct brain areas. We sought to explore whether and how repeated migraine attacks influence intrinsic brain connectivity, as well as how activity in these networks correlates with clinical indicators of migraine.Methods/Principal Findings: Resting-state fMRI data in twenty-three patients with migraines without aura (MwoA) and 23 age- and gender-matched healthy controls (HC) were analyzed using independent component analysis (ICA), in combination with a "dual-regression'' technique to identify the group differences of three important pain-related networks [default mode network (DMN), bilateral central executive network (CEN), salience network (SN)] between the MwoA patients and HC. Compared with the HC, MwoA patients showed aberrant intrinsic connectivity within the bilateral CEN and SN, and greater connectivity between both the DMN and right CEN (rCEN) and the insula cortex - a critical region involving in pain processing. Furthermore, greater connectivity between both the DMN and rCEN and the insula correlated with duration of migraine.Conclusions: Our findings may provide new insights into the characterization of migraine as a condition affecting brain activity in intrinsic connectivity networks. Moreover, the abnormalities may be the consequence of a persistent central neural system dysfunction, reflecting cumulative brain insults due to frequent ongoing migraine attacks.