Uric acid is a risk factor for myocardial infarction and stroke - The Rotterdam Study
Uric acid is a risk factor for myocardial infarction and stroke - The Rotterdam Study
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DOI：
10.1161/01.str.0000221716.55088.d4
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发表时间：
2006-06-01
期刊：
影响因子：
8.3
通讯作者：
Breteler, Monique M. B.
中科院分区：
文献类型：
--
作者：
Bos, Michiel J.;Koudstaal, Peter J.;Breteler, Monique M. B.
背景和目的：尿酸作为心肌梗死危险因素的作用是有争议的，而其作为卒中危险因素的作用知之甚少。最近的证据表明，尿酸可能是心血管疾病的一个重要致病因素，例如，通过诱导肾脏疾病和高血压。我们调查了血清尿酸和冠心病和中风之间的关联在一个大的前瞻性人群为基础的study.Methods -这项研究是基于4385名参与者的鹿特丹研究谁，在基线（1990年至1993年），年龄>= 55岁，无中风和冠心病，并采取了血液。对卒中和心肌梗死事件的随访完成至2002年1月1日。数据进行了分析，考克斯比例风险模型与调整相关confersider.Results -平均随访时间为8.4年。高血清尿酸水平与心肌梗死和卒中的风险相关;最高与最低五分位尿酸的年龄和性别调整风险比（95%CI）为1.68（1.24至2.27）心血管疾病（515例），1.87（1.12至3.13）心肌梗死缺血性脑卒中205例为1.77（1.10 ~ 2.83），出血性脑卒中46例为1.68（0.68 ~ 4.15）。对其他血管危险因素的校正仅轻微减弱了这些关联。无高血压者与高血压者的相关性更强。结论：尿酸是心肌梗死和卒中的一个强危险因素。
Background and Purpose - The role of uric acid as a risk factor for myocardial infarction is controversial, and little is known about its role as a risk factor for stroke. Recent evidence suggests that uric acid may be an important causal agent in cardiovascular disease, for example, by inducing renal disease and hence hypertension. We investigated the association between serum uric acid and coronary heart disease and stroke in a large prospective population-based study.Methods - The study was based on 4385 participants of the Rotterdam Study who, at baseline (1990 to 1993), were >= 55 years of age, free from stroke and coronary heart disease, and had blood taken. Follow-up for incident stroke and myocardial infarction was complete until January 1, 2002. Data were analyzed with Cox proportional hazards models with adjustment for relevant confounders.Results - Average follow-up was 8.4 years. High serum uric acid levels were associated with risk of myocardial infarction and stroke; age- and sex-adjusted hazard ratios (95% CIs) for highest versus lowest quintile of uric acid were 1.68 (1.24 to 2.27) for cardiovascular disease (515 cases), 1.87 (1.12 to 3.13) for myocardial infarction (194 cases), 1.57 (1.11 to 2.22) for stroke (381 cases), 1.77 (1.10 to 2.83) for ischemic stroke (205 cases), and 1.68 (0.68 to 4.15) for hemorrhagic stroke (46 cases). Adjustment for other vascular risk factors only slightly attenuated these associations. Associations were stronger in persons without hypertension than in those with hypertension.Conclusions - Uric acid is a strong risk factor for myocardial infarction and stroke.