Genes, pseudogenes, and Alu sequence organization across human chromosomes 21 and 22
Genes, pseudogenes, and Alu sequence organization across human chromosomes 21 and 22
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DOI：
10.1073/pnas.052692099
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发表时间：
2002-03-05
影响因子：
11.1
通讯作者：
Karlin, S
中科院分区：
文献类型：
--
作者：
Chen, CF;Gentles, AJ;Karlin, S
人类21号和22号染色体（主要是cl臂）是人类基因组的第一个完整部分。我们对这些染色体上的基因、假基因（psig）和Alu重复序列的分析发现：含有非翻译外显子的基因结构的数量超过25%，末端外显子往往是外显子中最大的，而起始内含子往往是内含子中最大的，单外显子基因长度约为平均基因外显子数乘以平均内部外显子长度;处理后的psig长度平均与单外显子基因长度大致相同; G+C含量与基因长度不相关。基因，psig，和Alu序列和G+C变异的计数和分布进行了评估相对于集群和过度分散。其他评估涉及比较基因间长度，psig序列的属性，以及Alu和psig序列之间的相关性。
Human chromosomes 21 and 22 (mainly the cl-arms) were the first complete parts of the human genome released. Our analysis of genes, pseudogenes (psig), and Alu repeats across these chromosomes include the following findings: The number of gene structures containing untranslated exons exceeds 25%; the terminal exon tends to be the largest among exons, whereas, the initial intron tends to be the largest among introns; single-exon gene length is approximately the mean gene exon number times the mean internal exon length; processed psig lengths are on average approximately the same as single-exon gene length; and the G+C content and length of genes are uncorrelated. The counts and distribution of genes, psig, and Alu sequences and G+C variation are evaluated with respect to clusters and overdispersions. Other assessments concern comparisons of intergenic lengths, properties of psig sequences, and correlations between Alu and psig sequences.