Non-invasive assessment of microvascular endothelial function by laser doppler flowmetry in patients with essential hypertension
Non-invasive assessment of microvascular endothelial function by laser doppler flowmetry in patients with essential hypertension
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DOI：
10.1016/j.atherosclerosis.2003.11.015
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发表时间：
2004-03-01
期刊：
影响因子：
5.3
通讯作者：
Farsang, C
中科院分区：
文献类型：
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作者：
Farkas, K;Kolossváry, E;Farsang, C
本研究的目的是用两种非侵入性激光多普勒技术检测高血压患者和正常血压受试者前臂皮肤的内皮依赖性血管扩张。本文观察了25例高血压病患者和25例正常血压对照者连续两次注射乙酰胆碱(ACh)和硝普钠(SNP)对皮肤微循环的影响，并对其闭塞后反应性充血(PORH)反应进行了观察。同时测定血浆血管性假血友病因子(VWF)水平和活性。PORH的平均峰值流量为287+/-31.5%(x+/-S.E.M.)高血压组410.28+/-35.08%，非高血压组35.08%(P
The aim of the study was to investigate the endothelium-dependent vasodilation in the forearm skin using two non-invasive laser Doppler applications in patients with essential hypertension (EHT) and in normotensive (NT) control subjects. The effect of two consecutive doses of acetylcholine (ACh) and that of sodium nitroprusside (SNP) on the skin microcirculation, and thereafter the postocclusive reactive hyperaemic (PORH) response, were measured in 25 patients with essential hypertension and also in 25 control normotensive healthy subjects. The plasma von Willebrand factor (vWF) level and activity were also determined. The average peakflow in PORH was 287+/-31.5% (x+/-S.E.M.) in EHT and 410.28+/-35.08% in NT (P