Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees.
Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees.
复制标题
双相情感障碍家系中产后情绪症状的家族聚集。
DOI：
10.1111/j.1399-5618.2008.00455.x
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发表时间：
2008
影响因子：
5.4
通讯作者：
Byerl
中科院分区：
文献类型：
--
作者：
Payne,JenniferL;MacKinnon,DeanF;Mondimore,FrancisM;McInnis,MelvinG;Schweizer,Barbara;Zamoiski,RachelB;McMahon,FrancisJ;NurnbergerJr,JohnI;Rice,JohnP;Scheftner,William;Coryell,William;Berrettini,WadeH;Kelsoe,JohnR;Byerl
目的：我们试图确定产后情绪症状和抑郁发作是否表现出家族聚集性在双相I pedigrees.Methods：共有1,130名妇女接受了采访，诊断性采访遗传研究的一部分，美国国家精神卫生研究所（NIMH）遗传学倡议双相障碍合作研究，并询问他们是否有过产后四周内出现情绪症状。妇女们还被问及是否有两个严重的抑郁发作的详细描述发生在产后。我们研究了产后情绪症状的女性同胞，谁以前怀孕，并有双相I，双相II，或双相情感（双相型）障碍（n = 303）的诊断，给予一个或多个亲属产后情绪symptoms.Results：产后情绪症状的家族聚集的优势比为2.31（p = 0.011）在任何情绪症状分析（n = 304），并增加到2.71（p = 0.005）时，躁狂症状被排除在外，虽然这是没有显着不同的任何情绪症状分析。 我们还研究了产后抑郁症发作的家庭聚集，然而，受试者的数量是small.Conclusions：研究的局限性，包括回顾性访谈，事实上，收集的数据用于其他目的和无法控制的药物使用等因素。与以前的研究一起，这些数据提供了支持的假设，可能有一个遗传基础的特质产后情绪症状一般和产后抑郁症状，特别是在妇女与双相情感障碍。结合该特征的遗传连锁和关联研究是有必要的。
Objectives:We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees.Methods:A total of 1,130 women were interviewed with the Diagnostic Interview for Genetic Studies as part of the National Institute of Mental Health (NIMH) Genetics Initiative Bipolar Disorder Collaborative Study and were asked whether they had ever experienced mood symptoms within four weeks postpartum. Women were also asked whether either of two major depressive episodes described in detail occurred postpartum. We examined the odds of postpartum mood symptoms in female siblings, who had previously been pregnant and had a diagnosis of bipolar I, bipolar II, or schizoaffective (bipolar type) disorders (n = 303), given one or more relatives with postpartum mood symptoms.Results:The odds ratio for familial aggregation of postpartum mood symptoms was 2.31 (p = 0.011) in an Any Mood Symptoms analysis (n = 304) and increased to 2.71 (p = 0.005) when manic symptoms were excluded, though this was not significantly different from the Any Mood Symptoms analysis. We also examined familial aggregation of postpartum major depressive episodes; however, the number of subjects was small.Conclusions:Limitations of the study include the retrospective interview, the fact that the data were collected for other purposes and the inability to control for such factors as medication use. Taken together with previous studies, these data provide support for the hypothesis that there may be a genetic basis for the trait of postpartum mood symptoms generally and postpartum depressive symptoms in particular in women with bipolar disorder. Genetic linkage and association studies incorporating this trait are warranted.