Crimean-Congo Hemorrhagic Fever Knowledge, Attitudes, Practices, Risk Factors, and Seroprevalence in Rural Georgian Villages with Known Transmission in 2014.
Crimean-Congo Hemorrhagic Fever Knowledge, Attitudes, Practices, Risk Factors, and Seroprevalence in Rural Georgian Villages with Known Transmission in 2014.
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DOI：
10.1371/journal.pone.0158049
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Salyer SJ
中科院分区：
文献类型：
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作者：
Greiner AL;Mamuchishvili N;Kakutia N;Stauffer K;Geleishvili M;Chitadze N;Chikviladze T;Zakhashvili K;Morgan J;Salyer SJ
2014年，格鲁吉亚发现了自2009年开始监测以来最高的克里米亚-刚果出血热年度病例数。CCHF是一种高致死性的出血性综合征，由感染的蜱和动物血液传播。为了应对这一紧迫的公共卫生威胁，我们评估了CCHF危险因素，血清阳性率，以及CCHF相关知识，态度和做法，在12个农村报告2014年CCHF病例，告知CCHF预防和控制措施。随机选择住户进行访谈和血清样本采集。数据按无答复和性别加权;百分比反映加权情况。在618名受访者中，中位年龄为54.8岁（IQR：26.5，范围：18.6-101.4）; 215名（48.8%）为男性。大多数（91.5%）受试者报告了≥1次CCHF高风险活动。在389名接触蜱虫的参与者中，286名（46.7%）参与者徒手处理蜱虫; 65/216（29.7%）知道风险。在605名受访者中，355人（57.9%）报告了动物血液暴露; 32/281人（12.7%）知道风险。在612名受访者中，184人（28.8%）知道预防CCHF和蜱暴露的措施，但只有54.3%的人采取了措施。在435份血清样本中，12份抗CCHF IgG阳性，表明加权血清阳性率为3.0%。大多数（66.7%）血清阳性受试者报告了蜱暴露。在这些村庄中，CCHF危险因素普遍存在，而CCHF相关知识和预防措施有限;这些发现对于告知公共卫生干预措施以有效控制和预防持续的CCHF传播至关重要。此外，CCHF血清阳性率高于以前检测到的（0.03%），突出了这种疾病在南方高加索地区的重要性，并支持正在进行的区域调查。
In 2014 the highest annual case count of Crimean-Congo hemorrhagic fever (CCHF) was detected in Georgia since surveillance began in 2009. CCHF is a high-fatality hemorrhagic syndrome transmitted by infected ticks and animal blood. In response to this immediate public health threat, we assessed CCHF risk factors, seroprevalence, and CCHF-related knowledge, attitudes, and practices in the 12 rural villages reporting a 2014 CCHF case, to inform CCHF prevention and control measures. Households were randomly selected for interviewing and serum sample collection. Data were weighted by non-response and gender; percentages reflect weighting. Among 618 respondents, median age was 54.8 years (IQR: 26.5, range: 18.6–101.4); 215 (48.8%) were male. Most (91.5%) participants reported ≥1 CCHF high-risk activity. Of 389 participants with tick exposure, 286 (46.7%) participants handled ticks bare-handed; 65/216 (29.7%) knew the risk. Of 605 respondents, 355 (57.9%) reported animal blood exposure; 32/281 (12.7%) knew the risk. Of 612 responding, 184 (28.8%) knew protective measures against CCHF and tick exposures, but only 54.3% employed the measures. Of 435 serum samples collected, 12 were anti-CCHF IgG positive, indicating a weighted 3.0% seroprevalence. Most (66.7%) seropositive subjects reported tick exposure. In these villages, CCHF risk factors are prevalent, while CCHF-related knowledge and preventive practices are limited; these findings are critical to informing public health interventions to effectively control and prevent ongoing CCHF transmission. Additionally, CCHF seroprevalence is higher than previously detected (0.03%), highlighting the importance of this disease in the South Caucuses and in supporting ongoing regional investigations.