The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems.
The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems.
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DOI：
10.1002/anie.201603291
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发表时间：
2017-03-20
期刊：
影响因子：
--
通讯作者：
Liu HW
中科院分区：
文献类型：
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作者：
Lin CI;McCarty RM;Liu HW
为纪念真正的发现者或至少被认为是发现者而命名的化学反应被称为“命名反应”。这篇综述收集了命名的化学反应的生物学代表。重点放在反应类型和催化机制上，展示了天然产物生物合成中的化学多样性以及与合成有机化学的相似之处。在可能的情况下，已经尝试在它们的合成对应物的背景下描述催化的酶机制，并讨论那些目前活跃的研究领域的反应的机制假设。本综述按反应类型进行了分类，如缩合、亲核加成、还原和氧化、取代、羧基化、自由基介导和重排，并按命名反应进行了细分。
Chemical reactions that are named in honor of their true or at least perceived discoverers are known as “name reactions”. This review is a collection of biological representatives of named chemical reactions. Emphasis is placed on reaction types and catalytic mechanisms that showcase both the chemical diversity in natural product biosynthesis as well as the parallels with synthetic organic chemistry. An attempt has been made to describe the enzymatic mechanisms of catalysis within the context of their synthetic counterparts whenever possible and to discuss the mechanistic hypotheses for those reactions that are presently active areas of investigation. This review has been categorized by reaction type, e.g., condensation, nucleophilic addition, reduction and oxidation, substitution, carboxylation, radical-mediated, and rearrangements, which are subdivided by named reactions.