Hyperlipidemia and hyperinsulinemia in the spontaneous osteoarthritis mouse model, STR/Ort.
Hyperlipidemia and hyperinsulinemia in the spontaneous osteoarthritis mouse model, STR/Ort.
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DOI：
10.1538/expanim.58.181
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发表时间：
2009-04
影响因子：
2.4
通讯作者：
K. Uchida;K. Urabe;Kouji Naruse;Z. Ogawa;K. Mabuchi;M. Itoman
中科院分区：
文献类型：
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作者：
K. Uchida;K. Urabe;Kouji Naruse;Z. Ogawa;K. Mabuchi;M. Itoman
最近的研究集中在原发性骨关节炎和血脂异常之间的关联。 STR/Ort小鼠具有骨关节炎和高脂血症等独特特征，可能是研究血脂异常对原发性骨关节炎潜在机制影响的有用模型。然而，人们对 STR/Ort 小鼠的高脂血症特性知之甚少。在这项研究中，我们研究了 STR/Ort 小鼠的高脂血症和脂毒性。 STR/Ort小鼠具有类似人类高脂血症患者的症状，例如高胆固醇血症、高甘油三酯血症、高胰岛素血症、胰岛素抵抗、NEFA失调和低血清脂联素。即使当 STR/Ort 小鼠表现出高胰岛素血症时，也没有观察到其肝脏中过量的甘油三酯积聚。该信息可能对使用 STR/Ort 小鼠研究脂质代谢和原发性骨关节炎的研究人员有用。
Recent studies have focused on the association between primary osteoarthritis and dyslipidemia. STR/Ort mice have unique characteristics including osteoarthritis and hyperlipidemia, and may be a useful model for investigating the effect of dyslipidemia on the underlying mechanism of primary osteoarthritis. However, little is known about the hyperlipidemic properties of STR/Ort mice. In this study we investigated hyperlipidemia and lipotoxicity in STR/Ort mice. STR/Ort mice have human hyperlipidemic patient-like symptoms such as hypercholesteremia, hypertriglyceridemia, hyperinsulinemia, insulin resistance, dysregulation of NEFA, and low serum adiponectin. Excess triglyceride accumulation in the liver of STR/Ort mice was not observed even when they exhibited hyperinsulinemia. This information may be useful for researchers investigating lipid metabolism and primary osteoarthritis using STR/Ort mice.