Adderall® produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers
Adderall® produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers
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DOI：
10.1007/s00213-006-0550-9
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发表时间：
2007-04-01
影响因子：
3.4
通讯作者：
Gerhardt, Greg A.
中科院分区：
文献类型：
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作者：
Joyce, B. Matthew;Glaser, Paul E. A.;Gerhardt, Greg A.
Adderall（(R)）目前用于治疗注意力缺陷多动障碍（ADHD），由大约24%的l -安非他明和76%的d -安非他明盐的新型混合物组成。然而，没有对这种组合在体内的药理作用的研究。采用Nafion（(R)）涂层单碳纤维微电极高速计时电流测定技术，研究了麻醉雄性Fischer 344 （F344）大鼠纹状体中Adderall（(R)）、D-安非他明（D， l -安非他明）引起的安非他明诱发多巴胺（DA）释放。安非他明溶液通过压力喷射从微移液管局部施用。与D-安非他明和D， l -安非他明相比，局部应用Adderall（(R)）导致DA释放信号幅值显著增加，多巴胺释放和再摄取的时间延长。这些数据支持了Adderall((R))p中安非他明对映体和盐的组合对DA释放有影响的假设，与D-和D， l -安非他明相比，这导致DA释放增加和延长。
Rationale Adderall((R)) is currently used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD) and is composed of a novel mixture of approximately 24% L-amphetamine and 76% D-amphetamine salts. There are, however, no investigations of the pharmacological effects of this combination in vivo.The technique of high-speed chronoamperometry using Nafion((R))-coated single carbon-fiber microelectrodes was used to study amphetamine-evoked dopamine (DA) release produced by Adderall((R)), D-amphetamine, or D,L-amphetamine in the striatum of anesthetized male Fischer 344 (F344) rats. The amphetamine solutions were locally applied from micropipettes by pressure ejection.Local applications of Adderall((R)) resulted in significantly greater DA release signal amplitudes with prolonged time course of dopamine release and re-uptake as compared to D-amphetamine and D,L-amphetamine.These data support the hypothesis that the combination of amphetamine enantiomers and salts in Adderall((R))p has effects on DA release, which result in increased and prolonged DA release, compared to D- and D,L-amphetamine.