A volumetric study of MRI signal hyperintensities in late-life depression
A volumetric study of MRI signal hyperintensities in late-life depression
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DOI：
10.1176/appi.ajgp.12.6.606
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发表时间：
2004-11-01
影响因子：
7.2
通讯作者：
O'Brien, JT
中科院分区：
文献类型：
--
作者：
Firbank, MJ;Lloyd, AJ;O'Brien, JT
目的：老年抑郁症患者的白质病变增加。作者调查了抑郁症受试者和正常受试者之间的区域位置是否不同，并确定了磁共振（MR）信号高强度与血管疾病已知临床危险因素的关系。研究方法：作者使用自动化图像处理软件确定老年抑郁症患者（N = 29;平均年龄：76岁）和相似年龄的正常受试者（N=32）的MR脑扫描信号高信号体积。结果如下：总的来说，抑郁症患者的额叶白质病变体积明显大于正常人（0.35%比0.22%）。然而，在排除了高血压、糖尿病或缺血性心脏病的受试者（留下14名抑郁症受试者和15名正常受试者）后，我们发现两组之间的差异更大，抑郁症组额叶区域的MR信号高信号体积更大，但基底节或顶叶和枕叶没有差异。结论：研究结果支持“血管性抑郁”假说，并表明那些患有抑郁症但没有传统血管危险因素的人可能比正常人更容易患脑血管疾病。这种增加易感性的机制仍有待确定。
Objective: An increase in white-matter lesions has been previously described in older subjects with depression. The authors investigated whether the regional location varied between depressed and normal subjects and determined the relationship of magnetic resonance (MR) signal hyperintensities to known clinical risk factors for vascular disease. Methods: Authors used automated image-processing software to determine volumes of signal hyperintensities from MR brain scans of older people with depression (N = 29; mean age: 76 years) and normal subjects of similar age (N=32). Results: Overall, subjects with depression had a significantly greater frontal-lobe white-matter lesion volume than normal subjects (0.35% versus 0.22%). However, after excluding subjects with hypertension, diabetes, or ischemic heart disease (leaving 14 depressed and 15 normal subjects), we found even greater differences between groups, with a larger volume of MR signal hyperintensities in the frontal region of the depressed group, but no difference in the basal ganglia or parietal and occipital lobes. Conclusion: The results support the "vascular depression" hypothesis and suggest that those with depression but without traditional vascular risk factors may be much more susceptible to cerebrovascular disease than normal subjects. The mechanisms for this increased susceptibility remain to be determined.