The relation between dopamine oxidation currents in the nucleus accumbens and conditioned increases in motor activity in rats following repeated administration of d-amphetamine or cocaine
The relation between dopamine oxidation currents in the nucleus accumbens and conditioned increases in motor activity in rats following repeated administration of d-amphetamine or cocaine
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DOI：
10.1046/j.1460-9568.1998.00124.x
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发表时间：
1998-03-01
影响因子：
3.4
通讯作者：
Phillips, AG
中科院分区：
文献类型：
--
作者：
Di Ciano, P;Blaha, CD;Phillips, AG
计时电流记录技术被用来监测细胞外多巴胺流出与无条件和条件的增加，在大鼠的运动活动，无论是d-苯丙胺（0.63毫克/公斤）或可卡因（3毫克/公斤），静脉给药后，或呈现条件刺激配对反复与这些精神兴奋剂之一。每天给予每种药物，持续7天，无论是在饲养笼中还是在存在复合刺激（光偏移、气味）的环境中。对照组大鼠在不同的测试环境中接受生理盐水而不是药物。在第7天的训练，非条件运动活动的显着增加，观察到在30分钟的会议后，无论是d-安非他明或可卡因的输液。相关的多巴胺氧化电流在脑桥核增加后立即给药的任何一种药物，并保持显着高于基线在整个30分钟的记录期间。在测试当天，呈现的条件刺激与车辆输注，在不同的环境中，伴随着增加多巴胺氧化电流和运动活动的条件增加，只有在这些刺激已配对的组中与d-苯丙胺或可卡因。条件运动活动的幅度和持续时间都与丘脑核细胞外多巴胺流出的相应变化不匹配。因此，有人认为，多巴胺浓度的增加作为一个神经化学相关的非条件和条件刺激。运动活动的变化构成了非条件反应和条件反应，这些反应受到细胞外多巴胺初始升高激活的神经系统的影响。
Chronoamperometric recording techniques were used to monitor extracellular dopamine efflux in the nucleus accumbens associated with unconditioned and conditioned increases in motor activity in rats, following the intravenous administration of either d-amphetamine (0.63 mg/kg) or cocaine (3 mg/kg), or the presentation of a conditioned stimulus paired repeatedly with one of these psychostimulants. Each drug was administered daily for 7 days, either in the home cage or an environment in which a compound stimulus (light offset, odour) was presented. Rats in control groups received saline instead of drug in the distinctive test environment. On day 7 of training, significant increases in unconditioned motor activity were observed in the 30 min session following infusions of either d-amphetamine or cocaine. Associated dopamine oxidation currents in the nucleus accumbens increased immediately following administration of either drug and remained significantly elevated above baseline during the entire 30 min recording period. On the test day, presentation of the conditioned stimulus with vehicle infusions, in the distinct environment, was accompanied by an increase in dopamine oxidation currents and a conditioned increase in motor activity, only in the groups in which these stimuli had been paired with d-amphetamine or cocaine. Neither the magnitude or duration of the conditioned motor activity matched the corresponding change in extracellular dopamine efflux in the nucleus accumbens. Accordingly, it is argued that the increase in dopamine concentration serves as a neurochemical correlate of the unconditioned and conditioned stimuli. The change in motor activity constitutes the unconditioned and conditioned responses that are subserved by the neural systems activated by the initial rise in extracellullar dopamine.