Enduring alterations in neurophysiological taste responses after early dietary sodium deprivation.
Enduring alterations in neurophysiological taste responses after early dietary sodium deprivation.
复制标题
早期饮食钠剥夺后神经生理味觉反应的持久改变。
DOI：
10.1152/jn.1993.69.3.832
复制
发表时间：
1993
影响因子：
2.5
通讯作者：
Hill,DL
中科院分区：
文献类型：
--
作者：
Vogt,MB;Hill,DL
1. 研究了四组大鼠在钠盐、非钠盐、柠檬酸和蔗糖的化学刺激下，孤束核（NST）神经元的味觉反应。四组大鼠分别为：从受孕后第3天至出生后至少第50天饲喂0.03% NaCl的缺盐饮食（缺盐组大鼠）、发育初期饲喂缺盐饮食，成年后再饲喂补盐饮食（缺盐组大鼠）5周或5周，以及一直饲喂补盐饮食（对照组大鼠）。2. 与对照组相比，发育早期开始的饮食中NaCl的剥夺导致对钠盐的平均反应频率大大降低（高达50%），但对非钠盐和非盐刺激的平均反应频率没有降低。同时，大多数被剥夺大鼠的NST神经元对NH4Cl的反应最好，而对NaCl的反应最好。这与在对照组中观察到的结果相反，在对照组中，相同比例的神经元对NaCl和NH4Cl的反应最好。3. 与对照组相比，康复大鼠的味觉反应表现出对许多钠盐的高反应性。也就是说，钠盐引起的平均反应频率明显高于对照组（高达100%）。对NaCl和NH4Cl反应最好的神经元比例与被剥夺大鼠相反。在恢复的大鼠中，对NaCl反应最好的神经元比例远远大于对NH4Cl反应最好的神经元比例。4. 成年后仅被剥夺饮食NaCl的大鼠的反应与对照组相同。因此，环境操纵必须发生在发育的早期阶段。5. 这些发现表明，钠的早期饮食操纵和随后的饮食钠的替代对钠引起的味觉反应具有相对选择性的神经生理影响。此外，由于恢复大鼠的记录是在喂食充满NaCl的饮食后bb0或= 5周获得的，因此早期的NaCl剥夺似乎永久性地改变了NTS的功能组织。虽然外周神经活动的改变可能在NTS神经元对味觉刺激的功能发育中起作用，但其他非活动相关因素也可能很重要。
1. Neurophysiological taste responses from neurons in the nucleus of the solitary tract (NST) were studied in four groups of rats during chemical stimulation of the tongue with sodium and non-sodium salts, citric acid, and sucrose. The four groups of rats consisted of those fed a NaCl-deficient diet (0.03% NaCl) from day 3 postconception to at least day 50 postnatal (deprived rats), rats initially fed the NaCl-deficient diet during development and then placed on a NaCl-replete diet at adulthood for > or = 5 wk (control-deprived rats), and rats always fed the NaCl-replete diet (control rats). 2. Compared with controls, dietary NaCl deprivation instituted early in development resulted in highly attenuated average response frequencies to sodium salts (as much as 50%) but not to nonsodium salts and nonsalt stimuli. Concomitantly, most NST neurons in deprived rats responded “best” to NH4Cl and few responded best to NaCl. This is in contrast to that observed in controls, where the same proportion of neurons responded best to NaCl and best to NH4Cl. 3. Taste responses in recovered rats exhibited a hyperresponsiveness to many sodium salts compared with controls. That is, sodium salts elicited average response frequencies significantly greater (as much as 100%) than that obtained in controls. The proportions of neurons responding best to NaCl or to NH4Cl were opposite to that in deprived rats. In recovered rats, the proportion of neurons that responded best to NaCl was much greater than that which responded best to NH4Cl. 4. Rats deprived of dietary NaCl only as adults responded like controls. Therefore the environmental manipulations must occur during early periods of development. 5. These findings show that early dietary manipulations of sodium and subsequent replacement of dietary sodium have neurophysiological effects relatively selective for sodium-elicited taste responses. Furthermore, because recordings in recovered rats were obtained > or = 5 wk after feeding the NaCl-replete diet, it appears as though early NaCl deprivation permanently alters the functional organization of the NTS. Although it is likely that alterations in peripheral neural activity play a role in the functional development of NTS neurons responsive to taste stimuli, other non-activity-related factors may also be important.