Introduction-basement membranes: From the matrisome to beyond.
Introduction-basement membranes: From the matrisome to beyond.
复制标题
介绍-基底膜：从基质体到基质体以外。
DOI：
10.1002/jemt.20561
复制
发表时间：
2008
影响因子：
2.5
通讯作者：
McCarthy,KevinJ
中科院分区：
文献类型：
--
作者：
McCarthy,KevinJ
用于其它基质细胞蛋白质的局部保留或作为生长因子、细胞因子和其它生物活性分子的储存“仓库”。存在于许多细胞-细胞界面的片状聚合物基质（图3）继续吸引着许多人，尽管在基底膜领域的具体研究似乎在逐渐下降（图1）。具有讽刺意味的是，20世纪80年代研究基底膜生物学的还原论方法最终在一般科学界获得了对这种基质及其组成分子的批判性认识，对该领域的人来说是一把双刃剑。毫无疑问，20世纪80年代和90年代的开创性研究大大提高了我们对基底膜分子结构和组织的认识。同时，我们可能没有向我们领域之外的人传达关于基底膜生物学的基本概念的重要性，这些基本概念是由那些研究人员在20世纪60年代和70年代首先提出的，即这种聚合物片在细胞中的生物活性。
stations’’for the localized retention of other matricellular proteins or as storage ‘‘depots’’for growth factors, cytokines, and other bioactive molecules. The sheetlike polymeric matrix (Fig. 3) that exists at many cell–cell interfaces continues to fascinate many, despite the indices that specific research in the area of basement membranes appears to be on a gradual decline (Fig. 1). Ironically, the former reductionistic approaches to the study of basement membrane biology of the 1980s, which ultimately gained the critical recognition of this matrix and its constituent molecules in the general scientific community, has been a doubleedged sword to those in the field. There is no doubt that our knowledge of the molecular structure and organization of the basement membrane has been significantly enhanced by seminal research studies of 1980s and 1990s. At the same time, we may have failed to convey to those outside of our field the importance of the basic concepts about basement membrane biology first put forth by those investigators in the 1960s and 1970s—that the bioactivity of this polymeric sheet in