Elevated levels of serum advanced glycation end products in patients with non-alcoholic steatohepatitis
Elevated levels of serum advanced glycation end products in patients with non-alcoholic steatohepatitis
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DOI：
10.1111/j.1440-1746.2007.04943.x
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发表时间：
2007-07-01
影响因子：
4.1
通讯作者：
Tazuma, Susumu
中科院分区：
文献类型：
--
作者：
Hyogo, Hideyuki;Yamagishi, Sho-ichi;Tazuma, Susumu
背景和目的：糖基化终末产物（AGE）是糖尿病患者体内加速形成的衰老蛋白衍生物，在糖尿病血管并发症的发病机制中起重要作用。近年来，AGE也被发现与胰岛素抵抗有关。虽然非酒精性脂肪性肝炎（NASH）通常被认为是胰岛素抵抗的肝脏表现，但没有报告显示AGE与NASH的联系。本研究的目的是评估AGE在NASH患者中的临床意义。方法：从106名患者的血清中测定甘油醚衍生的AGE水平：66名NASH患者，10名单纯脂肪变性患者和30名对照者。NASH患者血清甘油三脂来源的AGE水平（U/mL）显著升高（9.78 +/- 3.73）与单纯脂肪变性（7.17 +/- 2.28，P = 0.018）或健康对照（6.96 +/- 2.36，P = 0.003）相比。此外，这些与脂联素呈负相关，脂联素是一种具有胰岛素增敏和抗炎特性的脂肪细胞因子。此外，免疫组化的甘油三脂衍生的AGE表现出强烈的染色在肝脏的NASH patients.Conclusions：目前的数据表明，持续增加的甘油三脂衍生的AGE可以至少在一定程度上有助于NASH的发病机制。血清甘油三酸酯衍生的AGE水平可能是鉴别NASH与单纯性脂肪变性的有用生物标志物。
Background and Aim: Advanced glycation end products (AGE), senescent macroprotein derivatives formed at an accelerated rate in diabetes, play important roles in the pathogenesis of diabetic vascular complications. Recently, AGE have also been found to be involved in insulin resistance. Although non-alcoholic steatohepatitis (NASH) is generally considered a hepatic manifestation of insulin resistance, there are no reports showing the link of AGE to NASH. The aim of this study was to evaluate the clinical significance of AGE in patients with NASH.Methods: Glyceraldehyde-derived AGE levels were assayed from serum obtained from 106 patients: 66 with NASH, 10 with simple steatosis, and 30 controls.Results: Serum glyceraldehyde-derived AGE levels (U/mL) were significantly elevated in NASH patients (9.78 +/- 3.73) compared with simple steatosis (7.17 +/- 2.28, P = 0.018) or healthy controls (6.96 +/- 2.36, P = 0.003). Moreover, these were inversely correlated with adiponectin, an adipocytokine with insulin-sensitizing and anti-inflammatory properties. In addition, immunohistochemistry of glyceraldehyde-derived AGE showed intense staining in the livers of NASH patients.Conclusions: The present data suggest that the sustained increase of glyceraldehyde-derived AGE could at least in part contribute to the pathogenesis of NASH. The serum glyceraldehyde-derived AGE level may be a useful biomarker for discriminating NASH from simple steatosis.