QUANTITATION OF ANTEGRADE AND RETROGRADE BLOOD-FLOW IN THE HUMAN AORTA BY MAGNETIC-RESONANCE VELOCITY MAPPING
QUANTITATION OF ANTEGRADE AND RETROGRADE BLOOD-FLOW IN THE HUMAN AORTA BY MAGNETIC-RESONANCE VELOCITY MAPPING
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DOI：
10.1016/0002-8703(89)90399-2
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发表时间：
1989-06-01
影响因子：
4.8
通讯作者：
LONGMORE, DB
中科院分区：
文献类型：
--
作者：
BOGREN, HG;KLIPSTEIN, RH;LONGMORE, DB
本文应用磁共振速度图对24例正常人的升主动脉近端和中段进行二维速度分布研究，并对正向和反向血流进行定量。通过与所有受试者的左心室每搏输出量比较以及与12例受试者的肺动脉血流测量结果比较，验证了主动脉血流测量结果。协议是良好的标准误差的估计值为7.8和7.1毫升，相关系数分别为0.93和0.95。近端主动脉和升主动脉中段的收缩期流速图相似，最大早期收缩期血流沿着左后壁。在收缩末期和整个二尖瓣，在升主动脉中段的同一区域形成了一个反向流动通道，但在主动脉近端，它分裂进入主动脉窦，主要是左冠状窦和右冠状窦。逆行与顺行血流的平均百分比为6.3%，大多数逆行血流发生在早期栓塞。研究结果表明，逆行血流与冠状动脉血流有关，并且已知影响主动脉血流模式的主动脉疾病也可能影响冠状动脉血流。
Magnetic resonance velocity mapping was used in 24 normal subjects to study two-dimensional velocity profiles in the proximal and mid-ascending aorta, and to quantify both forward and reverse flow. The aortic flow measurements were validated by comparison with left ventricular stroke volume in all subjects and by comparison with pulmonary flow measurements in 12. Agreement was good with standard errors of the estimate of 7.8 and 7.1 ml, and correlation coefficients of 0.93 and 0.95, respectively. Systolic velocity maps were similar in the proximal aorta and the mid-ascending aorta, with maximum early systolic flow along the left posterior wall. Toward the end of systole and throughout diastole, a channel of reverse flow developed in the same region in the mid-ascending aorta, but in the proximal aorta it split to enter the sinuses of Valsalva, predominantly the left and the right coronary sinuses. Mean percentage ratio of retrograde-to-anterograde flow was 6.3%, with the majority of retrograde flow occurring in early diastole. The findings suggest that the retrograde flow is related to coronary artery flow and it is possible that aortic disease, which is known to influence aortic flow patterns, may also influence coronary flow.