Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome.
Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome.
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DOI：
10.1186/1546-0096-9-15
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发表时间：
2011-07-13
期刊：
影响因子：
--
通讯作者：
Agematsu K
中科院分区：
文献类型：
--
作者：
Shigemura T;Yamazaki T;Hara Y;Ou JN;Stevens AM;Ochs HD;Koike K;Agematsu K
全身性幼年特发性关节炎（sJIA）是一种全身性炎症性疾病，其特征在于关节炎、尖峰热和皮疹，其经常并发巨噬细胞活化综合征（MAS），一种危及生命的疾病。我们报告一个22个月大的女孩与sJIA谁开发严重MAS，但成功地治疗皮质类固醇，环孢素A，和非甾体抗炎药监测血清IL-18水平。IL-18是监测sJIA和MAS活性的非常有用的细胞因子，血清IL-18可用作治疗有效性和决定停止治疗的指标。
Systemic juvenile idiopathic arthritis (sJIA) is a systemic inflammatory disease characterized by arthritis, spiking fever and a skin rash that is frequently complicated by macrophage activation syndrome (MAS), a life-threatening disorder. We report a 22-month-old girl with sJIA who developed severe MAS but was successfully treated with corticosteroids, cyclosporin A, and non-steroidal anti-inflammatory drugs by monitoring serum IL-18 levels. IL-18 is an extremely useful cytokine for monitoring the activity of sJIA and MAS, and serum IL-18 can be used as an indicator for the effectiveness of treatment and the decision to discontinue therapy.
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影响因子：
5.1
作者：
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Kishimoto, T
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Yachie, Akihiro
影响因子：
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作者：
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通讯作者：
Murray, KJ
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作者：
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通讯作者：
Grom, Alexei A.