BMP-2-induced bone formation and neural inflammation
BMP-2-induced bone formation and neural inflammation
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DOI：
10.1016/j.jor.2017.03.003
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发表时间：
2017-06-01
影响因子：
1.5
通讯作者：
James, Aaron W.
中科院分区：
文献类型：
--
作者：
Nguyen, Vi;Meyers, Carolyn A.;James, Aaron W.
骨形态发生蛋白-2 (BMP-2) 是一种来自转化生长因子β (TGF-b) 家族的有效骨诱导细胞因子，是目前最常用的基于蛋白质的骨移植替代品。尽管近年来 BMP-2 的临床使用显着增加，但其突出的地位也凸显了各种不良事件，包括诱导炎症。本综述将阐明BMP-2与炎症之间的关系，重点是周围神经炎症及其后遗症。此外，我们还回顾了神经释放因子与 BMP2 在骨形成过程中的潜在附加作用。 (C) 2017 PK Surendran 教授纪念教育基金会。由 RELX India, Pvt. 旗下部门 Elsevier 出版。有限公司保留所有权利。
Bone morphogenetic protein-2 (BMP-2), a potent osteoinductive cytokine from the transforming growth factor beta (TGF-b) family, is currently the most commonly used protein-based bone graft substitute. Although clinical use of BMP-2 has significantly increased in recent years, its prominence has also highlighted various adverse events, including induction of inflammation. This review will elucidate the relationship between BMP-2 and inflammation, with an emphasis on peripheral nerve inflammation and its sequelae. As well, we review the potential additive roles of nerve released factors with BMP2 in the context of bone formation. (C) 2017 Prof. PK Surendran Memorial Education Foundation. Published by Elsevier, a division of RELX India, Pvt. Ltd. All rights reserved.