Adhesive pyramidal thorn patches provide pain relief to athletes
Adhesive pyramidal thorn patches provide pain relief to athletes
复制标题
DOI：
10.1002/kjm2.12044
复制
发表时间：
2019-04-01
影响因子：
3.3
通讯作者：
Yoshioka, Tohru
中科院分区：
文献类型：
--
作者：
Saito, Norio;Shima, Rei;Yoshioka, Tohru
运动员的疼痛最好在没有全身药物的情况下治疗。因此，经常使用补充和替代医学，包括贴片治疗。然而，贴剂治疗产生的疼痛缓解的生理机制尚未得到很好的阐明。在本研究中，我们介绍了一种金字塔刺（PT）补丁，我们开发的，证明了这种PT补丁治疗各种类型的疼痛在300名受试者的影响，并提出了一个生理机制的疼痛缓解效果。一种PT贴剂治疗有效缓解了近一半受试者的疼痛。除了皮肤深处产生的疼痛，如腰痛，几乎所有受试者在使用PT贴剂的四次治疗中疼痛都消失了。有趣的是，在每次试验后，疼痛感应区域都沿着神经纤维移动。此外，不含PT的贴剂也提供了一些疼痛缓解。我们认为这种效应是由于皮肤上的毛发偏转;也就是说，PT贴片的粘附通过偏转毛囊直接激活默克尔细胞以及毛囊周围的默克尔细胞-神经突复合体，而没有PT的贴片的粘附仅激活默克尔细胞-神经突复合体。在任何情况下，贴片粘附都会刺激A β纤维来缓解疼痛。最后，我们发现电刺激可以提高痛阈，这表明PT贴片的温和粘附会更有效。据我们所知，这是第一个研究，以证明生理上的有效性，粘附贴剂缓解疼痛。
Pain in athletes is ideally treated without systemic medicine. Therefore, complementary and alternative medicine, including patch treatments, is often used. The physiologic mechanisms of pain relief produced by patch treatment, however, are not well elucidated. In the present study, we introduce a pyramidal thorn (PT) patch that we developed, demonstrate the effects of this PT patch for the treatment of various types of pain in 300 subjects, and suggest a physiologic mechanism for the pain relief effects. One treatment with the PT patch effectively relieved pain in almost half the subjects evaluated. Except for pain generated deeply under the skin, such as low-back pain, pain was eliminated within four treatments with the PT patch in almost all of the subjects. Interestingly, the pain-sensing region moved along the nerve fibers after each trial. Further, patches without PT also provided some pain relief. We considered that this effect was due to hair deflection on the skin; that is, adhesion of the PT patch activates Merkel cells directly as well as Merkel cell-neurite complexes around the hair follicles by deflecting the hair follicles, whereas adhesion of a patch without PT only activates the Merkel cell-neurite complexes. In any case, patch adhesion stimulates A beta fibers to alleviate pain. Finally, we found that the pain threshold is increased by electric stimulation, suggesting that the gentle adhesion of a PT patch would be more effective. To our knowledge, this is the first study to demonstrate physiologically the validity of an adherent patch for pain relief.